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首页> 外文期刊>Circulation. Cardiovascular imaging >Rationale and design of a multicenter echocardiographic study to assess the relationship between cardiac structure and function and heart failure risk in a biracial cohort of community-dwelling elderly persons: The atherosclerosis risk in communities study
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Rationale and design of a multicenter echocardiographic study to assess the relationship between cardiac structure and function and heart failure risk in a biracial cohort of community-dwelling elderly persons: The atherosclerosis risk in communities study

机译：多中心超声心动图研究的原理和设计，以评估社区居住的老年人的混血儿队列中心脏结构和功能与心力衰竭风险之间的关系：社区研究中的动脉粥样硬化风险

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Background-Heart failure is an important public health concern, particularly among persons >65 years of age. Women and blacks are critically understudied populations that carry a sizeable portion of the heart failure burden. Limited normative and prognostic data exist on measures of cardiac structure, diastolic function, and novel measures of systolic deformation in older adults living in the community. Methods and Results-The Atherosclerosis Risk in Communities (ARIC) study is a large, predominantly biracial, National Heart, Lung, and Blood Institute-sponsored epidemiological cohort study. Between 2011 and 2013, ?6000 surviving participants, now in their seventh to ninth decade of life, are expected to return for a fifth study visit during which comprehensive 2-dimensional, Doppler, tissue Doppler, and speckle-tracking echocardiography will be performed uniformly in all cohort clinic visit participants. The following objectives will be addressed: (1) to characterize cardiac structural and functional abnormalities among the elderly and to determine how they differ by sex and race/ethnicity, (2) to determine the relationship between ventricular and vascular abnormalities, and (3) to prospectively examine the extent to which these noninvasive measures associate with incident heart failure. Conclusions-We describe the design, imaging acquisition and analysis methods, and quality assurance metrics for echocardiography in visit 5 of the ARIC cohort. A better understanding of the differences in cardiac structure and function through the spectrum of heart failure stages in elderly persons generally, and between sexes and racial/ethnic groups specifically, will deepen our understanding of the pathophysiology driving heart failure progression in these at-risk populations and may inform novel prevention or therapeutic strategies.
机译：背景心脏衰竭是重要的公共卫生问题，尤其是在> 65岁的人群中。妇女和黑人是受到严重忽视的人群，他们承担着相当一部分心力衰竭负担。在居住在社区的老年人中，关于心脏结构，舒张功能和新的收缩变形的测量方法的规范和预后数据有限。方法和结果-社区中的动脉粥样硬化风险（ARIC）研究是一项大型的混血儿，国家心脏，肺和血液研究所发起的流行病学队列研究。在2011年至2013年之间，预计将有6000名尚在世的人，他们已经处于其第七至九十岁的生命中，将进行第五次研究访问，在此期间，将统一进行全面的二维，多普勒，组织多普勒和斑点跟踪超声心动图检查所有队列诊所的访问参与者。将实现以下目标：（1）表征老年人的心脏结构和功能异常，并确定其在性别和种族/民族方面的差异;（2）确定心室和血管异常之间的关系;以及（3）前瞻性地检查这些非侵入性措施与心力衰竭相关的程度。结论-我们在ARIC队列的第5次访问中描述了超声心动图的设计，成像采集和分析方法以及质量保证指标。通常，通过老年人心力衰竭阶段的频谱，尤其是性别与种族/族裔群体之间，对心脏结构和功能差异的更好理解，将加深我们对这些高危人群中驱动心力衰竭进展的病理生理学的认识并可能提供新颖的预防或治疗策略。

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