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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Protective Effect of Mesona procumbens against tert-Butyl Hydroperoxide-lnduced Acute Hepatic Damage in Rats
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Protective Effect of Mesona procumbens against tert-Butyl Hydroperoxide-lnduced Acute Hepatic Damage in Rats

机译：异丙肾上腺素对叔丁基过氧化氢诱导的大鼠急性肝损伤的保护作用

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摘要

The protective effect of Hsian-tsao (Mesona procumbens Hemsl.) and its active compounds on liver damage was evaluated using the model of tert-butyl hydroperoxide (t-BHP)-induced acute hepatic damage in rats.Male Sprague-Dawley rats (200+-10 g) were orally pretreated with a water extract of Hsian-tsao (WEHT) (0.1,0.5,and 1.0 g/kg) or caffeic acid (0.1 g/kg of body weight) for 13 days before a single dose of t-BHP (0.2 mmol/kg,intraperitoneally) to each animal,and the rats were sacrificed 18 h later by decapitation;blood samples were collected for the assays of serum biochemical values.The livers were excised from the animals and assayed for oxidative injury,antioxidant enzyme,and pathological histology.The result showed that the oral pretreatment of WEHT (0.1,0.5,and 1.0 g/kg) or caffeic acid (0.10 g/kg) before t-BHP (0.2 mmol/kg) treatment significantly lowered the serum levels of the hepatic enzyme markers (alanine aminotransferase,aspartate aminotransferase,and lactate dehydrogenase) and reduced oxidative stress of the liver by evaluation of malondialdehyde,glutathione,8-hydroxy-2'-deoxyguanosine,glutathione peroxidase,and glutathione reductase.The histopathological evaluation of the rat livers showed that WEHT and caffeic acid reduced the incidence of liver lesions including cloudy swelling,pyknosis,and cytolysis induced by t-BHP in rats.On the basis of the results of this study,it can be speculated that M.procumbens protects liver against f-BHP-induced hepatic damage in rats.
机译：使用叔丁基过氧化氢（t-BHP）诱导的大鼠急性肝损伤模型评估了Hsian-tsao（Mesona procumbens Hemsl。）及其活性化合物对肝脏损伤的保护作用。雄性Sprague-Dawley大鼠（200 + -10克）在每次单剂量服用之前，先用先贤水提取物（WEHT）（0.1、0.5和1.0 g / kg）或咖啡酸（0.1 g / kg体重）口服预处理13天。每只动物以t-BHP（0.2 mmol / kg，腹膜内）处死，断头处死大鼠18 h;收集血样以测定血清生化值。从动物中切除肝脏并测定氧化损伤结果表明，在进行t-BHP（0.2 mmol / kg）治疗之前，口服WEHT（0.1、0.5和1.0 g / kg）或咖啡酸（0.10 g / kg）的口服预处理明显降低血清肝酶标志物（丙氨酸转氨酶，天冬氨酸转氨酶和乳酸脱氢酶）的水平通过评价丙二醛，谷胱甘肽，8-羟基-2'-脱氧鸟苷，谷胱甘肽过氧化物酶和谷胱甘肽还原酶降低肝脏的氧化应激。对大鼠肝脏的组织病理学评估表明，WEHT和咖啡酸可降低包括t-BHP引起的大鼠浑浊肿胀，萎缩和细胞溶解。根据这项研究的结果，可以推测procumbens可以保护肝脏免受f-BHP引起的大鼠肝损伤。

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