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首页> 外文期刊>Journal of applied biological chemistry >Induction of Glutathione S-transferase Activity by the Extracts of Glycyrrhiza uralensis Fischer
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Induction of Glutathione S-transferase Activity by the Extracts of Glycyrrhiza uralensis Fischer

机译：甘草Fischer提取物诱导谷胱甘肽S-转移酶活性

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摘要

In the present study, we investigated the glutathione S-transferase (GST) induction of medicinal plants using a cultured PC12 cells. The methanol extracts of Dendrobium nobile Lindley, Schizonepeta tenuifolia Briquet, Glycyrrhiza uralensis Fischer, Paenoia lactiflora Pall were tested. As the result, exposure of PC12 cells to G uralensis resulted in the significant induction of GST. On the continuous experiment, G uralensis was extracted with methanol, ethanol, and acetone. Among these extracts, methanol extracts showed the highest GST induction. The methanol extracts were further fractionated with hexane, diethyl ether, ethyl acetate, and water layer according to the degree of polarity. The diethyl ether layer showed the highest exhibited GST induction on PC12 cells. Based on these results suggest that the extracts of G uralensis can be applicable for the development of a new antioxidant agent.
机译：在本研究中，我们调查了使用培养的PC12细胞对药用植物的谷胱甘肽S-转移酶（GST）的诱导。测试了石D石Lind，裂叶荆芥，甘草，费氏,、 Pa药的甲醇提取物。结果，PC12细胞暴露于Guralensis导致了显着的GST诱导。在连续实验中，用甲醇，乙醇和丙酮萃取了山耳。在这些提取物中，甲醇提取物显示出最高的GST诱导。根据极性的程度，用己烷，乙醚，乙酸乙酯和水层进一步分离甲醇提取物。乙醚层在PC12细胞上表现出最高的GST诱导作用。基于这些结果表明，可将甘草提取物用于开发新型抗氧化剂。

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