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首页> 外文期刊>Journal of AOAC International >Simultaneous determination of Danshensu, salvianolic acid B, and paeonol in ShuangDan oral liquid by HPLC.
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Simultaneous determination of Danshensu, salvianolic acid B, and paeonol in ShuangDan oral liquid by HPLC.

机译：高效液相色谱法同时测定双丹口服液中丹参素，丹酚酸B和丹皮酚的含量。

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摘要

An HPLC-photodiode array detector (PDAD) method was developed for simultaneous determination of danshensu, salvianolic acid B, and paeonol in a traditional Chinese medicinal preparation ShuangDan oral liquid, which is widely used to treat coronary heart disease in China. The samples were separated on a SinoChrom ODS-BP C18 column with the column temperature maintained at 30 degrees C. The mobile phase was composed of methanol and 2% (v/v) glacial acetic acid at a flow rate of 1.0 mL/min. The separation was finished within 30 min using linear gradient elution. All calibration curves showed good linearity (r>0.9997) within the test ranges. The method was simple, reliable, accurate, and specific. The intraday and interday precisions (RSD) were less than 0.85%. The recoveries were between 96.97 and 102.14%. The method was successfully applied to the determination of the three components in three commercial samples of ShuangDan oral liquid. The results indicated that the developed HPLC-PDAD assay could be readily utilized as a comprehensive quality control method for ShuangDan oral liquid.
机译：建立了同时测定传统双冠口服液中丹参素，丹酚酸B和丹皮酚含量的高效液相色谱-光电二极管阵列检测器（PDAD）。样品在SinoChrom ODS-BP C 18 色谱柱上分离，色谱柱温度保持在30摄氏度。流动相由甲醇和2％（v / v）冰醋酸组成。流速为1.0 mL / min。使用线性梯度洗脱在30分钟内完成分离。在测试范围内，所有校准曲线均显示出良好的线性（r> 0.9997）。该方法简单，可靠，准确，专一。日内和日间精度（RSD）小于0.85％。回收率在96.97和102.14％之间。该方法成功地用于双丹口服液的三种市售样品中三种成分的测定。结果表明，所开发的HPLC-PDAD测定方法可轻松用作双丹口服液的综合质量控制方法。

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