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首页> 外文期刊>Circulation research: a journal of the American Heart Association >The Success Story of LDL Cholesterol Lowering
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The Success Story of LDL Cholesterol Lowering

机译：低密度脂蛋白胆固醇降低的成功故事

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We can look back at > 100 years of cholesterol research that has brought medicine to a stage where people at risk of severe or fatal coronary heart disease have a much better prognosis than before. This progress has not come about without resistance. Perhaps one of the most debated topics in medicine, the cholesterol controversy, could only be brought to rest through the development of new clinical research methods that were capable of taking advantage of the amazing achievements in basic and pharmacological science after the second World War. It was only after understanding the biochemistry and physiology of cholesterol synthesis, transport and clearance from the blood that medicine could take advantage of drugs and diets to reduce the risk of atherosclerotic diseases. This review points to the highlights of the history of low-density lipoprotein-cholesterol lowering, with the discovery of the low-density lipoprotein receptor and its physiology and not only the development of statins as the stellar moments but also the development of clinical trial methodology as an effective tool to provide scientifically convincing evidence.
机译：我们可以回顾一下> 100多年来的胆固醇研究，该研究使药物进入了一个阶段，在这个阶段中，患有严重或致命性冠心病风险的人的预后要好得多。没有阻力就不会取得这一进展。胆固醇争议也许是医学上争议最大的话题之一，只有通过开发能够利用第二次世界大战后基础医学和药理学领域令人惊讶的成就的新临床研究方法，才能解决这一问题。只有了解了胆固醇的合成，运输和从血液中清除后的生物化学和生理学，药物才可以利用药物和饮食来降低动脉粥样硬化疾病的风险。这篇评论指出了低密度脂蛋白胆固醇降低的历史，其中发现了低密度脂蛋白受体及其生理特性，不仅是他汀类药物作为恒星时刻的发展，而且是临床试验方法的发展作为提供科学依据的有效工具。

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