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首页> 外文期刊>Journal of Applied Polymer Science >Model Polypeptide of Mussel Adhesive Protein. l. Syntjhesis and Adhesive Studies of Sequential polypeptides (X-Tyr-Lys)_n and (Y-Lys)_n
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Model Polypeptide of Mussel Adhesive Protein. l. Syntjhesis and Adhesive Studies of Sequential polypeptides (X-Tyr-Lys)_n and (Y-Lys)_n

机译：贻贝粘附蛋白的模型多肽。 l。 （X-Tyr-Lys）_n和（Y-Lys）_n序列多肽的合成和粘附研究

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The sequential polytripeptides and polydipeptides, (X-Tyr-Lys)_n, (X=Gly, Ala, Pro, Ser, Leu, Ile, Phe), (Y-Lys)_n, (Y=Gly, Tyr), and (Gly-Tyr)_n, which imitate a mussel adhesive protein, have been synthesized. The molecular weights of the polypeptides were estimated to be 7,200 ～ 13,400 (19 ～ 42 repeating units), and the polypeptides were found to have satisfactory amino acid sequences. The polypeptides were crosslinked by tyrosinase, and the optimal pH in the crosslinking reaction was 7.4 in the case of the polytripeptide, (Gly-Tyr-lys)_n. The optimal tyrosinase amount for the adhesive strength of (Gly-Tyr-Lys)_n was 0.34 unit/mg (polypeptide) at pH 7.4. The shear adhesive strength of the polytripeptide increased with an increase in the polytripeptide concentration, and was not influenced by the third amino acid, X. The shear adhesive strengths of polytripeptides (X-Tyr-Lys)_n were equal to one of the synthetic polydecapeptides, (Ala-Lys-Pro-Ser-Tyr-pro-Pro-Thr-Tyr-lys)_n and (Gly-Pro-Lys-Thr-Tyr-Pro-Pro-Thr-Tyr-Lys)_n which were the model polydecapeptides for blue mussel and Californian mussel, respectively.
机译：顺序的三肽和多肽（X-Tyr-Lys）_n，（X = Gly，Ala，Pro，Ser，Leu，Ile，Phe），（Y-Lys）_n，（Y = Gly，Tyr）和（已经合成了模仿贻贝粘附蛋白的Gly-Tyr）_n。该多肽的分子量估计为7,200〜13,400（19〜42个重复单元），并且发现该多肽具有令人满意的氨基酸序列。多肽通过酪氨酸酶交联，而在多肽（Gly-Tyr-lys）_n的情况下，交联反应中的最佳pH为7.4。 （Gly-Tyr-Lys）_n的粘合强度的最佳酪氨酸酶量在pH 7.4时为0.34单位/ mg（多肽）。多肽的剪切粘合强度随多肽浓度的增加而增加，并且不受第三氨基酸X的影响。多肽（X-Tyr-Lys）_n的剪切粘合强度等于合成的多肽的其中一种，（Ala-Lys-Pro-Ser-Tyr-pro-Pro-Thr-Tyr-lys）_n和（Gly-Pro-Lys-Thr-Tyr-Pro-Pro-Thr-Tyr-Lys）_n蓝贻贝和加利福尼亚贻贝的多十肽。

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