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首页> 外文期刊>Journal of Applied Polymer Science >Anticoagulant Surface Prepared by the Heparinization of Ionic Polyurethane Film
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Anticoagulant Surface Prepared by the Heparinization of Ionic Polyurethane Film

机译：离子聚氨酯薄膜肝素化制备抗凝表面

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摘要

We present a new method for heparinization on the surface of polyurethane. The segmented polyurethane was first modified with an epoxide monomer and followed by a ring-opening reaction with diethanolamine to introduce sufficient hydroxyl groups on the surface of cast film. On this film surface, a cationic monomer was grafted by using tetravalent Cerium slat as an initiator. Heparin was immobilized in high efficiency on the ionized surface through static interactions in aqueous solution. The structure of ionized and heparinized surfaces were characterized by attenuated total reflectance infrared spectroscopy (ATR-FTIR) and electron spectroscopy for chemical analysis (ESCA) spectra. The platelet-rich plasma (PRP) contacting test and the platelet-poor plasma (PPP) clotting time measurements showed that the immobilized heparin retained its strong anticoagulant property. The release of heparin from film into salt solution was also studied, and it was found that only a small portion of heparin (10-20%) was released over a period as long as 10 h. It is expected that this new method for surface heparinizaiton can be used to prepare antithrombogenic materials with long-term stability.
机译：我们提出了一种在聚氨酯表面进行肝素化的新方法。首先用环氧单体对链段聚氨酯进行改性，然后与二乙醇胺进行开环反应，以在流延膜的表面引入足够的羟基。在该膜表面上，通过使用四价铈板条作为引发剂接枝阳离子单体。肝素通过水溶液中的静态相互作用高效地固定在离子化表面上。电离和肝素化表面的结构通过衰减全反射红外光谱（ATR-FTIR）和电子光谱化学分析（ESCA）光谱进行表征。富血小板血浆（PRP）接触测试和贫血小板血浆（PPP）凝结时间测量表明，固定化肝素保留了其强大的抗凝特性。还研究了肝素从薄膜中释放到盐溶液中的过程，发现在长达10小时的时间内，只有一小部分肝素（10-20％）被释放。预期这种用于表面肝素化的新方法可用于制备具有长期稳定性的抗血栓形成材料。

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