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首页> 外文期刊>Journal of Applied Polymer Science >Release of Indomethacin from a Novel Chitosan Microsphere Prepared by a Naturally Occurring Crosslinker: Examination of Crosslinking and Polycation-Anionic Drug Interaction
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Release of Indomethacin from a Novel Chitosan Microsphere Prepared by a Naturally Occurring Crosslinker: Examination of Crosslinking and Polycation-Anionic Drug Interaction

机译：从由天然存在的交联剂制备的新型壳聚糖微球中释放消炎痛：交联和聚阳离子-阴离子药物相互作用的检验

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摘要

Novel chitosan micro spheres with lower cytotoxicity were fabricated in this study and their drug release characteristics were investigated. Genipin, a naturally occurring crosslinking reagent that has been used in herbal medicine and in the production of food dye, was used to prepare crosslinked chitosan microspheres by a water-in-oil dispersion method. The crosslinking mechanism examined by FTIR and ~(13)C-NMRsuggests that the crosslinking of chitosan by genipin leads to the formation of secondary amide and heterocyclic amino linkage. The polycation-anionic drug inter- action between chitosan and indomethacin was pH dependent and could affect the dissolution property of indomethacin. By examination of the release profiles of the crosslinked chitosan microsphere, it was found that the release of indomethacin from the microsphere was sustainable and influenced by factors such as crosslinking of microsl?here and chitosan-indomethacin interaction, thus establishing crosslinked chitosan microsphere as a very promising polymeric carrier for drug release.
机译：本研究制备了具有较低细胞毒性的新型壳聚糖微球，并研究了它们的药物释放特性。 Genipin是一种天然存在的交联剂，已用于草药和食用染料的生产中，已通过油包水分散法用于制备交联的壳聚糖微球。 FTIR和〜（13）C-NMR检验了交联机理，这表明，用genipin进行壳聚糖的交联会导致仲酰胺和杂环氨基键的形成。壳聚糖和消炎痛之间的聚阳离子-阴离子药物相互作用是pH依赖性的，并可能影响消炎痛的溶解性能。通过检查交联的壳聚糖微球的释放曲线，发现吲哚美辛从微球的释放是可持续的，并受微胶交联和壳聚糖-吲哚美辛相互作用等因素的影响，从而建立了交联的壳聚糖微球。有希望的用于药物释放的聚合物载体。

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