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首页> 外文期刊>Journal of Applied Polymer Science >Antibacterial Action of Chitosan and Carboxymethylated Chitosan
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Antibacterial Action of Chitosan and Carboxymethylated Chitosan

机译：壳聚糖和羧甲基化壳聚糖的抗菌作用

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摘要

A series of chitosan with different molecular weights obtained by 'Y-irradi- ation depolymerization and another series of deacetylated chitosan were synthesized. Several N ,O-carboxymethylated chitosan and O-carboxymethylated chitosan were also produced. The above samples were characterized by Fourier transform infrared spec- troscopy (FTIR). Their antibacterial activities against E. coli were explored by the optical density method. The antibacterial activity of chitosan is influenced by its molecular weight, degree of deacetylation, concentration in solution, and pH of the medium. Antibacterial activities were also found to be increased in the order of N,O- carboxymethylated chitosan, chitosan, and O-carboxymethylated chitosan. Fluores- cence of the FITC (fluorescein isothiocyanate)-labeled chitosan oligomers at the inside of the E. coli cell was observed by a confocal laser scanning microscope. The antibac- terial activity of chitosan oligomers seems to be caused mainly by the inhibition of the transcription from DNA.
机译：合成了一系列通过'Y'辐射解聚得到的不同分子量的壳聚糖和另一系列的脱乙酰壳聚糖。还生产了几种N，O-羧甲基化壳聚糖和O-羧甲基化壳聚糖。通过傅立叶变换红外光谱（FTIR）对以上样品进行了表征。用光密度法研究了它们对大肠杆菌的抗菌活性。壳聚糖的抗菌活性受其分子量，脱乙酰度，溶液浓度和培养基pH值的影响。还发现抗菌活性按N，O-羧甲基化壳聚糖，壳聚糖和O-羧甲基化壳聚糖的顺序增加。用共聚焦激光扫描显微镜观察到了FITC（异硫氰酸荧光素）标记的壳聚糖低聚物的荧光。壳聚糖低聚物的抗菌活性似乎主要是由于抑制了DNA的转录。

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