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首页> 外文期刊>Journal of Applied Polymer Science >Swelling behavior of hydrogels for colon-site drug delivery
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Swelling behavior of hydrogels for colon-site drug delivery

机译：用于结肠部位药物递送的水凝胶的溶胀行为

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Hydrogels based on n-alkyl methacrylate esters (n-AMA), acrylic acid, and acrylamide crosslinked with 4,4'-di(methacryloylamino)azobenzene were prepared. Swelling behavior of the hydrogels was studied by the immersion of slabs in buffered solutions at pH 2.2-7.4. The diffusion of water into the slabs was discussed on the stress relaxation model of polymer chains. The results obtained are in good agreement with Schott's second-order diffusion kinetics. The constants A and B of Schott's kinetics equation depend on the balance of hydrophobicity/hydrophilicity, the rigidity/flexibility, and the degree of crosslinking. The factors that exert the greatest influence on the swelling behavior of the gels include the degree of crosslinking, the lengths of the n-AMA side chains, and pH values. By adjusting these factors, the degree of swelling of the hydrogels in the small intestine can be controlled, and consequently the drugs may avoid being released before arriving in the colon. (C) 2002 John Wiley Sons, Inc. [References: 22]
机译：制备了基于甲基丙烯酸正烷基酯（n-AMA），丙烯酸和与4,4'-二（甲基丙烯酰基氨基）偶氮苯交联的丙烯酰胺的水凝胶。通过将平板浸入pH 2.2-7.4的缓冲溶液中来研究水凝胶的溶胀行为。利用聚合物链的应力松弛模型讨论了水向平板中的扩散。获得的结果与肖特的二阶扩散动力学非常吻合。肖特动力学方程的常数A和B取决于疏水性/亲水性，刚度/柔韧性和交联度之间的平衡。对凝胶的溶胀行为影响最大的因素包括交联度，n-AMA侧链的长度和pH值。通过调节这些因素，可以控制小肠中水凝胶的溶胀程度，因此可以避免药物在到达结肠之前被释放。 （C）2002 John Wiley Sons，Inc. [参考：22]

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