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首页> 外文期刊>Journal of Applied Polymer Science >Synthesis, degradation, and drug delivery of cycloaliphatic poly(ester anhydride)s
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Synthesis, degradation, and drug delivery of cycloaliphatic poly(ester anhydride)s

机译：脂环族聚（酯酐）的合成，降解和药物传递

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摘要

The high melting point of poly(1,4-cyclohexanedicarboxylic anhydride) [poly(CHDA)] is a disadvantage, in that it is intractable in the melting process of a drug delivery system. This report relates to diols introduced into the polyanhydride main chain to decrease its melting point. Various poly(ester anhydride)s containing ethylene glycol, 1,3-propanediol, 1,4-butanediol, or 1,6-hexandiol [poly(CHDA-XDO)] were synthesized by the esterification reaction and melt polycondensation. FTIR, DSC, WAXD, and intrinsic viscosity of polymers were recorded and hydrolytic degradation, as well as in vitro drug delivery, was conducted. The results show that the samples are stable in an anhydrous environment at room temperature and degrade in water following a surface erosion mechanism. The degradation period of poly(CHDA-XDO) ranged from 130 to 320 h as a result of the different diols and amounts of XDO introduced. The in vitro drug delivery gave 130-350 h of stable delivery along with the typical surface erosion mechanism. (C) 2002 Wiley Periodicals, Inc. [References: 26]
机译：聚（1，4-环己烷二羧酸酐）[聚（CHDA）]的高熔点是不利的，因为它在药物递送系统的熔融过程中难以控制。该报告涉及引入聚酸酐主链以降低其熔点的二醇。通过酯化反应和熔融缩聚，合成了包含乙二醇，1，3-丙二醇，1，4-丁二醇或1，6-己二醇的各种聚（酯酐）[聚（CHDA-XDO）]。记录FTIR，DSC，WAXD和聚合物的特性粘度，并进行水解降解以及体外药物递送。结果表明，样品在室温下的无水环境中是稳定的，并且由于表面腐蚀机理而在水中降解。由于二醇和引入的XDO的数量不同，聚（CHDA-XDO）的降解时间为130-320 h。体外药物递送与典型的表面腐蚀机理一起提供了130-350小时的稳定递送。 （C）2002 Wiley Periodicals，Inc. [参考：26]

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