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首页> 外文期刊>Journal of Applied Polymer Science >SYNTHESIS OF CROSSLINKED POLY(VINYL ALCOHOL) WITH L-PROLINE PENDANT AS THE CHIRAL STATIONARY PHASE FOR RESOLUTION OF AMINO ACID ENANTIOMERS
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SYNTHESIS OF CROSSLINKED POLY(VINYL ALCOHOL) WITH L-PROLINE PENDANT AS THE CHIRAL STATIONARY PHASE FOR RESOLUTION OF AMINO ACID ENANTIOMERS

机译：以L-脯氨酸侧链为手性固定相的交联聚乙烯醇的拆分。

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摘要

The porous crosslinked poly(vinyl alcohol) beads with the L-proline pendant was synthesized as the chiral stationary phase (CSP) for ligand-exchange chromatography of amino acid racemates via suspension polymerization of vinyl acetate and triallyl isocyanurate as a crosslinker, methanolysis of the copolymer, glycidylation of the formed crosslinked poly(vinyl alcohol), and final functionalization with L-proline. After the polymer with the chiral ligand was complexed with copper(II) cations, it was employed as the CSP to resolve the enantiomers of 15 amino acids. The results showed that the CSP possessed powerful enantioselectivity and all the tried amino acid racemates were completely separated. The large loadability (up to 60 mg per injection) permitted its application on a large scale. (C) 1996 John Wiley & Sons, Inc. [References: 22]
机译：通过醋酸乙烯酯和三烯丙基异氰脲酸酯作为交联剂的悬浮聚合，甲醇的甲醇解共聚物，形成的交联聚乙烯醇的缩水甘油基化以及用L-脯氨酸的最终官能化。将具有手性配体的聚合物与铜（II）阳离子络合后，将其用作CSP来解析15个氨基酸的对映异构体。结果表明，CSP具有很强的对映选择性，所有尝试的氨基酸外消旋物均已完全分离。大负载能力（每次注射最多60毫克）使其得以大规模应用。 （C）1996 John Wiley＆Sons，Inc. [参考：22]

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