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首页> 外文期刊>Journal of Applied Polymer Science >Preparation of core-shell type nanoparticles of diblock copolymers of poly(L-lactide)/poly(ethylene glycol) and their characterization in vitro
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Preparation of core-shell type nanoparticles of diblock copolymers of poly(L-lactide)/poly(ethylene glycol) and their characterization in vitro

机译：聚（L-丙交酯）/聚（乙二醇）二嵌段共聚物核壳型纳米粒子的制备及其体外表征

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Core-shell type nanoparticles of poly(L-lactide)/poly(ethylene glycol) (LE) diblock copolymer were prepared by a dialysis technique. Their size was confirmed as 40-70 nm using photon correlation spectroscopy. The H-1-NMR analysis confirmed the formation of core-shell type nanoparticles and drug loading. The particle size, drug loading, and drug release rate of the LE nanoparticles were slightly changed by the initial solvents that were used. The drug release behavior of LE core-shell type nanoparticles showed an initial burst during the first 12 h and then a sustained release until 100 h. The degradation behavior of LE block copolymer nanoparticies was divided into three phases: the initial rapid degradation phase, the stationary phase, and the rapid degradation phase until complete degradation. It was suggested that lidocaine release kinetics were predominantly governed by the diffusion mechanism in the initial burst phase and after that by both of the diffusion and degradation mechanisms. (C) 2002 Wiley Periodicals, Inc. [References: 26]
机译：通过透析技术制备了聚（L-丙交酯）/聚（乙二醇）（LE）二嵌段共聚物的核-壳型纳米颗粒。使用光子相关光谱法确认它们的尺寸为40-70nm。 H-1-NMR分析证实了核-壳型纳米颗粒的形成和载药量。 LE纳米颗粒的粒径，载药量和药物释放速率因使用的初始溶剂而略有变化。 LE核-壳型纳米颗粒的药物释放行为在最初的12小时内显示出最初的爆发，然后持续释放直至100小时。 LE嵌段共聚物纳米颗粒的降解行为分为三个阶段：初始快速降解阶段，固定阶段和快速降解阶段直到完全降解。有人认为利多卡因的释放动力学主要由爆发初期的扩散机制决定，其后由扩散和降解机制共同控制。 （C）2002 Wiley Periodicals，Inc. [参考：26]

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