• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Applied Polymer Science >gamma-irradiation preparation of poly(acrylic acid)-chitosan hydrogels for in vitro drug release
【24h】

gamma-irradiation preparation of poly(acrylic acid)-chitosan hydrogels for in vitro drug release

机译：体外释放药物的聚（丙烯酸）-壳聚糖水凝胶的γ辐射制备

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Biocompatible and biodegradable pH-responsive hydrogels based on poly(acrylic acid) and chitosan were prepared for controlled drug delivery. These interpolymeric hydrogels were synthesized by a gamma-irradiation polymerization technique. The degree of gelation was over 96% and increased as the chitosan or acrylic acid (AAc) content increased. The equilibrium swelling studies of hydrogels prepared under various conditions were carried out in an aqueous solution, and the pH sensitivity in a range of pH 1-12 was investigated. The AAc/chitosan hydrogels showed the highest water content when 30 vol % AAc and 0.1 wt % chitosan were irradiated with a 30 kGy dose of radiation. In addition, an increase of the degree of swelling with an increase in the pH was noticed and it had the highest value at pH 12. The drug 5-fluorouracil was loaded into these hydrogels and the release studies were carried out in simulated gastric and intestinal fluids. The in vitro release profiles of the drugs showed that more than 90% of the loaded drugs were released in the first 1 h at intestinal pH and the rest of the drug was released slowly. (C) 2003 Wiley Periodicals, Inc. [References: 25]
机译：制备了基于聚丙烯酸和壳聚糖的生物相容性和可生物降解的pH响应水凝胶，以控制药物的传递。这些共聚水凝胶是通过γ辐射聚合技术合成的。凝胶化程度超过96％，并随着壳聚糖或丙烯酸（AAc）含量的增加而增加。在水溶液中进行了在各种条件下制备的水凝胶的平衡溶胀研究，并研究了在pH 1-12范围内的pH敏感性。当用30 kGy的辐射量辐照30％体积的AAc和0.1％的壳聚糖时，AAc /壳聚糖水凝胶显示出最高的水含量。另外，注意到溶胀度随pH的增加而增加，并且在pH 12时具有最高的值。将5-氟尿嘧啶药物装入这些水凝胶中，并在模拟的胃和肠中进行了释放研究。液体。药物的体外释放曲线显示，在肠道pH值的最初1小时内，超过90％的载药已释放，其余药物则缓慢释放。 （C）2003 Wiley Periodicals，Inc. [参考：25]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号