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Endostatin's emerging roles in angiogenesis, lymphangiogenesis, disease, and clinical applications

机译:内皮抑素在血管生成,淋巴管生成,疾病和临床应用中的新兴作用

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摘要

Background: Angiogenesis is the process of neovascularization from pre-existing vasculature and is involved in various physiological and pathological processes. Inhibitors of angiogenesis, administered either as individual drugs or in combination with other chemotherapy, have been shown to benefit patients with various cancers. Endostatin, a 20-kDa C-terminal fragment of type XVIII collagen, is one of the most potent inhibitors of angiogenesis.
机译:背景:血管生成是来自现有血管的新血管形成过程,涉及各种生理和病理过程。已经显示,以单独药物或与其他化学疗法联合给药的血管生成抑制剂对患有各种癌症的患者有益。内皮抑素是XVIII型胶原的20 kDa C端片段,是最有效的血管生成抑制剂之一。

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