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首页> 外文期刊>Journal of Applied Polymer Science >Controlling absorbency in gelatin networks: Preparation and characterization of alkylated, crosslinked gelatin
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Controlling absorbency in gelatin networks: Preparation and characterization of alkylated, crosslinked gelatin

机译：控制明胶网络中的吸收性：烷基化交联明胶的制备和表征

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Gelatin is a highly abundant and relatively inexpensive protein which is used in a variety of gel applications including photography, drug delivery, microencapsulation, and food preparation. Control of network formation in gelatin may therefore provide methods of preparing protein gels tailored for specific applications. In this study, circular dichroism(CD), Raman, and nuclear magnetic resonance (NMR) spectroscopies were used to characterize ordering processes which occur in gelatin and their relationship to absorbency. Ordering of the unmodified protein, studied as a function of concentration, temperature, and time after initial preparation, correlates inversely with absorbency. Chemical modification was used to control the absorbency and solubility of the protein gels. Alkylation of gelatin using glycidyltrimethylammonium chloride causes substantial increases in water absorbency with degrees of substitution as low as 0.5%. Increases in saline swelling were observed only after additional modification of the alkylated gelatin with a nonionic polyoxyalkyleneamine crosslinking agent (Jeffamine(R)). Limiting the initial degree of substitution prior to crosslinking (to just below 1%) plays a key role in optimizing the absorbency and minimizing the dissolution of the gel in saline. The methods and principles used to manipulate the absorbency of gelatin may also find use for other natural protein systems. (C) 1998 John Wiley & Sons, Inc. [References: 19]
机译：明胶是一种高度丰富且相对便宜的蛋白质，可用于各种凝胶应用中，包括照相，药物输送，微囊化和食品制备。因此，对明胶中网络形成的控制可以提供制备针对特定应用的蛋白质凝胶的方法。在这项研究中，圆二色性（CD），拉曼光谱和核磁共振（NMR）光谱用于表征明胶中发生的有序过程及其与吸收性的关系。初始制备后，未经修饰的蛋白质的顺序与浓度，温度和时间有关，与吸收能力成反比。化学修饰用于控制蛋白质凝胶的吸收性和溶解性。使用缩水甘油基三甲基氯化铵进行明胶的烷基化会导致吸水率大幅提高，取代度低至0.5％。仅在用非离子型聚氧化烯胺交联剂（Jeffamine）对烷基化明胶进行进一步修饰之后，才观察到盐水溶胀的增加。将交联之前的初始取代度（仅略低于1％）限制在优化吸收性并使凝胶在盐水中的溶解最小化方面起着关键作用。用于操纵明胶吸收性的方法和原理也可用于其他天然蛋白质系统。 （C）1998 John Wiley＆Sons，Inc. [参考：19]

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