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首页> 外文期刊>Journal of Applied Polymer Science >Drug release behavior of electrical responsive poly(vinyl alcohol)/poly(acrylic acid) IPN hydrogels under an electric stimulus
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Drug release behavior of electrical responsive poly(vinyl alcohol)/poly(acrylic acid) IPN hydrogels under an electric stimulus

机译：电刺激下电响应性聚乙烯醇/聚丙烯酸IPN水凝胶的药物释放行为

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摘要

The electrically modulated properties of interpenetrating polymer networks (IPN) composed of poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAAc) under electric field were investigated for drug delivery systems. PVA/PAAc IPNs with various compositions were synthesized by a sequential method, that is, ultraviolet polymerization of AAc in the mixture of PVA and aqueous AAc monomer solution, followed by a freeze-thawing process to prepare elastic hydrogels. The amount of loaded drug significantly increased with the content of PAAc containing ionizable groups in IPN. The amount of introduced ionic drug (cefazoline) was greater than that of the nonionic drug (theophylline). Release behaviors of drug molecules from negatively charged PVA/PAAc IPN were switched on and off in a pulsatile pattern depending on the applied electric stimulus. The released amount and the release rate of drug were influenced significantly by the applied voltage, ionic group contents in IPN, ionic properties of drug solute, and the ionic strength of release medium. In addition, the ionic properties of drug molecules dramatically affected release behaviors, thus the release of ionic drug was much more enhanced than that of the nonionic drug.
机译：研究了由聚（乙烯醇）（PVA）和聚（丙烯酸）（PAAc）组成的互穿聚合物网络（IPN）在电场下的电调制性能。通过顺序方法合成具有不同组成的PVA / PAAc IPN，即在PVA和AAc单体水溶液的混合物中进行AAc的紫外线聚合，然后进行冻融工艺制备弹性水凝胶。随IPN中含PAAc的可电离基团的含量，载药量显着增加。离子药物（头孢唑啉）的引入量大于非离子药物（茶碱）的引入量。药物分子从带负电的PVA / PAAc IPN的释放行为取决于所施加的电刺激以脉冲模式打开和关闭。施加电压，IPN中的离子基团含量，溶质的离子性质以及释放介质的离子强度对药物的释放量和释放速率有显着影响。此外，药物分子的离子特性极大地影响了释放行为，因此离子药物的释放比非离子药物的释放要强得多。

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