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首页> 外文期刊>Journal of Applied Polymer Science >Merrifield resin and 1,6-hexanediol diacrylate-crosslinked polystyrene resin for solid-phase peptide synthesis: A comparative study
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Merrifield resin and 1,6-hexanediol diacrylate-crosslinked polystyrene resin for solid-phase peptide synthesis: A comparative study

机译：用于固相肽合成的Merrifield树脂和1,6-己二醇二丙烯酸酯交联的聚苯乙烯树脂：对比研究

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摘要

Three short peptides were synthesized on Merrifield resin (PS-DVB) and on polystyrene crosslinked with 1,6-hexanediol diacrylate resin (PS-HDODA) to compare their efficiencies in solid-phase peptide synthesis (SPPS). A 2% crosslinked polymeric system having almost equal capacity was used in both cases. The peptides were synthesized using standard solid-phase methodology. In the case of the PS-HDODA resin, all the couplings were completed by the first coupling and the peptides were obtained in >90% yield and >95% purity. But in the case of the PS-DVB resin, most of the attachments require two to three couplings and the peptides were obtained in about a 65% yield.
机译：在Merrifield树脂（PS-DVB）和与1,6-己二醇二丙烯酸酯树脂交联的聚苯乙烯（PS-HDODA）上合成了三种短肽，以比较它们在固相肽合成（SPPS）中的效率。在两种情况下均使用容量几乎相等的2％交联聚合物体系。使用标准固相方法合成肽。在PS-HDODA树脂的情况下，所有偶联均通过第一次偶联完成，并且以> 90％的收率和> 95％的纯度获得了肽。但是在PS-DVB树脂的情况下，大多数附件需要两到三个偶联，并且肽的收率约为65％。

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