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首页> 外文期刊>Circulation: An Official Journal of the American Heart Association >Some of the people, some of the time: susceptibility to acute rheumatic fever.
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Some of the people, some of the time: susceptibility to acute rheumatic fever.

机译：有些人，某些时候：易患急性风湿热。

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摘要

Acute rheumatic fever is a major cause of heart disease in large parts of the world, but it remains unknown why only a small fraction of those who are infected with rheumatogenic group A streptococci develop an abnormal immune response that leads to acute rheumatic fever. An understanding of the mechanisms underlying host susceptibility can provide important insights into pathogenesis that in turn can inform new treatments. Extensive searches for susceptibility factors have been undertaken, including human leukocyte antigens, B-cell alloantigens, and cytokine genes. Although significant associations have been found between genetic factors and acute rheumatic fever, study results often conflict with each other. This review explores current understanding about host susceptibility to acute rheumatic fever and provides an overall perspective to the number of studies that have recently addressed this subject.
机译：急性风湿热是世界上大部分地区心脏病的主要病因，但尚不清楚为什么只有一小部分感染了风湿病性A组链球菌的人会产生异常的免疫反应，从而导致急性风湿热。对宿主易感性机制的理解可以为发病机理提供重要的见解，进而为新的治疗方法提供依据。已经进行了广泛的敏感性因子搜索，包括人白细胞抗原，B细胞同种抗原和细胞因子基因。尽管已经发现遗传因素与急性风湿热之间存在显着关联，但研究结果经常相互冲突。这篇综述探讨了目前对宿主对急性风湿热的敏感性的理解，并为近期针对该主题的许多研究提供了整体视角。

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