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首页> 外文期刊>Journal of Applied Polymer Science >Preparation and anticoagulant property of phosphorylcholine-terminated o-benzoylchitosan derivative
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Preparation and anticoagulant property of phosphorylcholine-terminated o-benzoylchitosan derivative

机译：磷酸胆碱封端的邻苯甲酰壳聚糖衍生物的制备及抗凝血性能

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摘要

To improve the solubility in organic solvent of chitosan, o-benzoylchitosan was synthesized by acylation with benzoyl chloride and then used in the reaction with 2-chloro-1,3,2-dioxaphosphospholane (COP) to prepare phosphorylcholine-terminated o-benzoylchitosan (PC-BCS). PC-BCS had a structure with a phospholipid polar group characterized by FTIR and H-1 NMR. PC-BCS had been poly-substituted by a PC group, which made PC-BCS viscous liquid. The anticoagulant properties of PC-BCS were evaluated by means of blood-clotting and platelet adhesion assay. The blood-clotting assay indicated that PC-BCS could prolong the blood-clotting process. Platelet adhesion assay showed that PC-BCS could effectively inhibit the platelet adhesion and activation. (C) 2003 Wiley Periodicals, Inc. [References: 16]
机译：为了提高壳聚糖在有机溶剂中的溶解度，邻苯甲酰氯经酰化反应合成了邻苯甲酰壳聚糖，然后与2-氯-1,3,2-二氧杂磷膦烷（COP）反应制备磷酰胆碱封端的邻苯甲酰壳聚糖（ PC-BCS）。 PC-BCS具有通过FTIR和H-1 NMR表征的具有磷脂极性基团的结构。 PC-BCS已被PC基团多取代，从而使PC-BCS呈粘稠液体。 PC-BCS的抗凝特性通过凝血和血小板粘附测定进行评估。凝血试验表明，PC-BCS可以延长凝血过程。血小板粘附试验表明，PC-BCS可以有效抑制血小板的粘附和活化。 （C）2003 Wiley Periodicals，Inc. [参考：16]

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