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首页> 外文期刊>Journal of Applied Polymer Science >Stability and depolymerization of poly(sebacic anhydride) under high moisture environment
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Stability and depolymerization of poly(sebacic anhydride) under high moisture environment

机译：高湿环境下聚癸二酸酐的稳定性和解聚

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摘要

Polyanhydrides are found to be useful in drug delivery systems; however, these aliphatic polyanhydrides are also unstable under humidity and temperature (greater than 0degreesC) for their low toxicity and surface eroding mode of drug release. In this research, poly(sebacic anhydride) was synthesized for a stability and depolymerization study in high humidity a surrounding temperature of 35degreesC. According to the results from gel permeation chromatography, IR spectrophotometry, and differential scanning calorimetry investigations, it was found that both self-depolymerization and hydrolysis mechanisms existed during the depolymerization process for poly(sebacic anhydride) and they can be monitored directly. These results were further compared with previous research in a depolymerization study of polyanhydrides in a vacuum and in buffer solution. (C) 2003 Wiley Periodicals, Inc. [References: 17]
机译：发现聚酐可用于药物输送系统。然而，这些脂肪族聚酸酐由于其低毒性和药物释放的表面侵蚀模式，在湿度和温度（大于0℃）下也是不稳定的。在这项研究中，合成了聚癸二酸酐，用于在高湿度和35摄氏度的环境中进行稳定性和解聚研究。根据凝胶渗透色谱，红外分光光度法和差示扫描量热法研究的结果，发现聚癸二酸酐的解聚过程中同时存在自解聚和水解机理，可以对其进行直接监测。在真空和缓冲溶液中对聚酸酐进行解聚研究中，将这些结果与以前的研究作了进一步比较。 （C）2003 Wiley Periodicals，Inc. [参考：17]

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