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首页> 外文期刊>Journal of Applied Polymer Science >Thermoreversible hydrogels. XIX. Synthesis and swelling behavior and drug release behavior for the N-isopropylacrylamide/poly(ethylene glycol) methylether acrylate copolymeric hydrogels
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Thermoreversible hydrogels. XIX. Synthesis and swelling behavior and drug release behavior for the N-isopropylacrylamide/poly(ethylene glycol) methylether acrylate copolymeric hydrogels

机译：热可逆水凝胶。十九。 N-异丙基丙烯酰胺/聚（乙二醇）甲基醚丙烯酸酯共聚物水凝胶的合成，溶胀行为和药物释放行为

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摘要

A series of thermosensitive copolymeric hydrogels were prepared from various molar ratios of N-isopropylacrylamide (NIPAAm) and poly(ethylene glycol) methylether acrylate (PEGMEA(n)), which was synthesized from acryloyl chloride and poly(ethylene glycol) mono methylether with three oxyethylene chain lengths. Investigation of the effect of the chain length of oxyethylene in PEGMEA(n), and the amount of the PEGMEA(n), in the NIPAAm/PEGMEA(n) copolymeric gels, on swelling behavior in deionized water was the main purpose of this study. Results showed that the swelling ratio for the present copolymeric gels increased with increasing chain length of oxyethylene in PEGMEA(n) and also increased with increase in the amount of PEGMEA(n), in the copolymeric gels. However, the gel strength and effective crosslinking density of these gels decreased with increase in swelling ratio. Some kinetic parameters were also evaluated in this study. Finally, the drug release and drug delivery behavior for these gets were also assessed. (C) 2003 Wiley Periodicals, Inc. [References: 39]
机译：由N-异丙基丙烯酰胺（NIPAAm）和聚（乙二醇）甲基醚丙烯酸酯（PEGMEA（n））的不同摩尔比制备了一系列热敏共聚水凝胶，它们是由丙烯酰氯和聚（乙二醇）单甲基醚与三种氧乙烯链长。本研究的主要目的是研究PEGMEA（n）中的氧化乙烯链长以及NIPAAm / PEGMEA（n）共聚凝胶中PEGMEA（n）的量对去离子水中溶胀行为的影响。 。结果表明，在共聚凝胶中，本发明共聚凝胶的溶胀率随着氧乙烯在PEGMEA（n）中链长的增加而增加，并且也随PEGMEA（n）的量的增加而增加。但是，这些凝胶的凝胶强度和有效交联密度随着溶胀率的增加而降低。在这项研究中还评估了一些动力学参数。最后，还评估了这些药物的释放和释放行为。 （C）2003 Wiley Periodicals，Inc. [参考：39]

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