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首页> 外文期刊>Journal of Applied Polymer Science >TRANSPORT OF IONIZABLE DRUGS AND PROTEINS IN CROSSLINKED POLY(ACRYLIC ACID) AND POLY(ACRYLIC ACID-CO-2-HYDROXYETHYL METHACRYLATE) HYDROGELS .1. POLYMER CHARACTERIZATION
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TRANSPORT OF IONIZABLE DRUGS AND PROTEINS IN CROSSLINKED POLY(ACRYLIC ACID) AND POLY(ACRYLIC ACID-CO-2-HYDROXYETHYL METHACRYLATE) HYDROGELS .1. POLYMER CHARACTERIZATION

机译：交联的聚（丙烯酸）和聚（丙烯酸-CO-2-羟甲基丙烯酸甲酯）水合物中电离药物和蛋白质的运输1。聚合物表征

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摘要

The purpose of this investigation was to define the polymer structure and elucidate the swelling behavior of ionizable hydrophilic polymers (hydrogels) in water and buffered media. Poly(acrylic acid) (PAA) and poly(acrylic acid-co-2-hydroxyethyl methacrylate) [P(AA-co-HEMA)] hydrogels were synthesized with varying degrees of hydrophilicity and crosslinking and were designed as potential bioadhesive controlled-release dosage forms. The thermal initiation procedure employed during polymerization was optimized to eliminate unreacted residuals. Equilibrium and dynamic swelling studies were undertaken to determine the polymer mesh size and molecular weight between crosslinks of the hydrogels in the ionized and nonionized states. The PAA hydrogel mesh sizes ranged from 100 to 400 Angstrom over pH values of 3-7, whereas the P(AA-co-HEMA) hydrogel mesh sizes were between 13 and 140 Angstrom. These results demonstrated the significance of the swelling medium pH on the hydrated state of the polymers relative to crosslinking or copolymerization composition. (C) 1996 John Wiley & Sons, Inc. [References: 13]
机译：这项研究的目的是确定聚合物的结构，并阐明可电离的亲水性聚合物（水凝胶）在水和缓冲介质中的溶胀行为。合成了具有不同程度的亲水性和交联性的聚丙烯酸（PAA）和聚丙烯酸（甲基丙烯酸2-羟基-2-甲基乙基酯）[P（AA-co-HEMA）]水凝胶，并将其设计为潜在的生物粘合剂控释剂剂型。优化了聚合过程中采用的热引发程序，以消除未反应的残留物。进行了平衡和动态溶胀研究，以确定在电离和非电离状态下水凝胶交联之间的聚合物筛孔大小和分子量。在3-7的pH值范围内，PAA水凝胶筛孔的尺寸范围为100至400埃，而P（AA-co-HEMA）水凝胶筛孔的尺寸在13至140埃之间。这些结果证明了溶胀介质pH对聚合物相对于交联或共聚组合物的水合状态的重要性。 （C）1996 John Wiley＆Sons，Inc. [参考：13]

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