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首页> 外文期刊>Journal of Applied Polymer Science >Formation of antibiotic, biodegradable/bioabsorbable polymers by processing with neomycin sulfate and its inclusion compound with β-cyclodextrin
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Formation of antibiotic, biodegradable/bioabsorbable polymers by processing with neomycin sulfate and its inclusion compound with β-cyclodextrin

机译：通过硫酸硫酸新霉素及其与β-环糊精的包合化合物加工形成抗生素，可生物降解/可生物吸收的聚合物

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Samples of pure neomycin sulfate and its inclusion compound (IC) with β-cyclodextrin were implanted into films of poly(L-lactic acid) (PLLA) and poly(ε-caprolactone) (PCL). Both polymers have been widely used commercially to make sutures. The antibacterial activity of these films against Escherichia coli was tested. Films made by either solution casting or melt pressing were divided into the following three groups: (1) plain polymer films, (2) those embedded with pure neomycin sulfate, and (3) those embedded with neomycin sulfate-β-cyclodextrin IC. Filter paper treated with 1.5 μL of 10 mg/μL Kanamycin and neomycin were used as controls and resulted in 11- and 8-mm zones of inhibition/or antibacterial activity, respectively. Small discs (ca. 2% of total area) cut from solution-cast films of PLLA and PCL containing 50 wt % neomycin sulfate IC had 17- and 16-mm zones of inhibition, and PLLA and PCL containing 50 wt % pure neomycin sulfate deterred bacterial growth, resulting in 19-mm zones of inhibition. Melt-pressed films containing 10 wt % pure neomycin sulfate or its IC, showed 17- and 11-mm zones of inhibition for PLLA films, respectively, while PCL films showed 13- and 9-mm zones of inhibition, respectively. For melt-pressed films that contain 0.01 wt % pure neomycin sulfate or its IC, PLLA films showed 11- and 9.5-mm zones of inhibition, respectively, while PCL films showed 11- and 10-mm zones of inhibition, respectively. Since an antibiotic, bioabsorbable suture does not require surgical removal, implanting an inclusion compound in the suture might allow the slow release of antibiotic, thereby guarding against postsurgical infection and also protecting the antibiotic from degradation during the melt-spinning process used to make the suture.
机译：将纯硫酸新霉素及其包含β-环糊精的包合物（IC）的样品植入聚L-乳酸（PLLA）和聚ε-己内酯（PCL）的薄膜中。两种聚合物已在商业上广泛用于制造缝合线。测试了这些膜对大肠杆菌的抗菌活性。通过溶液流延或熔融压制制成的膜分为以下三组：（1）普通聚合物膜，（2）嵌入有纯硫酸新霉素的膜，和（3）嵌入有硫酸新霉素-β-环糊精IC的膜。将经1.5μL10 mg /μL卡那霉素和新霉素处理的滤纸用作对照，分别形成11毫米和8毫米的抑制/或抗菌活性区域。从含有50 wt％硫酸新霉素IC的PLLA和PCL溶液流延膜上切下的小圆盘（约占总面积的2％）具有17和16 mm的抑制区，而PLLA和PCL含有50 wt％的纯硫酸新霉素阻止了细菌的生长，导致了19毫米的抑制区。包含10 wt％的纯硫酸新霉素或其IC的熔体压膜对PLLA膜分别显示17和11毫米的抑制区，而PCL膜分别对13和9毫米显示抑制区。对于包含0.01 wt％的纯硫酸新霉素或其IC的熔融压制膜，PLLA膜分别显示11毫米和9.5毫米的抑制区域，而PCL膜分别显示11毫米和10毫米的抑制区域。由于抗生素，生物可吸收缝合线不需要手术移除，因此在缝合线中植入包涵物可能会使抗生素缓慢释放，从而防止术后感染，并防止抗生素在用于制造缝合线的熔体纺丝过程中降解。

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