A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo

Ohira Makoto; Iwasaki Yuka; Tanaka Chika; Kuroki Michitaka; Matsuo Naoki; Kitamura Tatsuhiko; Yukuhiro Masaki; Morimoto Hiroyuki; Pang Nisha; Liu Bei; Kiyono Tohru; Amemiya Masahide; Tanaka Kozo; Yoshida Kazumasa; Sugimoto Nozomi; Ohshima Takashi; Fujita Masatoshi

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A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo

机译：具有咔唑和苯并肼结构的新型抗微管剂可抑制体内肿瘤细胞的生长

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Background: The mitotic spindles are among the most successful targets of anti-cancer chemotherapy, and they still hold promise as targets for novel drugs. The anti-mitotic drugs in current clinical use, including taxanes, epothilones, vinca alkaloids, and halichondrins, are all microtubule-targeting agents. Although these drugs are effective for cancer chemotherapy, they have some critical problems; e.g., neurotoxicity caused by damage to neuronal microtubules, as well as innate or acquired drug resistance. To overcome these problems, a great deal of effort has been expended on development of novel anti-mitotics.

机译：背景：有丝分裂纺锤体是抗癌化学疗法最成功的靶标之一，它们仍有望作为新药的靶标。当前临床使用的抗有丝分裂药物，包括紫杉烷类，埃博霉素，长春花生物碱和halichondrins，都是靶向微管的药物。尽管这些药物对癌症化疗有效，但它们仍存在一些关键问题。例如，由对神经元微管的损害以及先天或获得的耐药性引起的神经毒性。为了克服这些问题，已经在新型抗有丝分裂剂的开发上进行了大量的努力。

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《Biochimica et Biophysica Acta. General Subjects》 |2015年第9期|共9页
作者
Ohira Makoto; Iwasaki Yuka; Tanaka Chika; Kuroki Michitaka; Matsuo Naoki; Kitamura Tatsuhiko; Yukuhiro Masaki; Morimoto Hiroyuki; Pang Nisha; Liu Bei; Kiyono Tohru; Amemiya Masahide; Tanaka Kozo; Yoshida Kazumasa; Sugimoto Nozomi; Ohshima Takashi; Fujita Masatoshi;
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正文语种 eng
中图分类生物化学;
关键词
Anti-mitotic agents; Anti-neoplastic agents; Centrosome; Microtubules; Mitotic spindle;

机译：抗有丝分裂剂;抗肿瘤剂;中心体;微管;有丝分裂纺锤体;
入库时间 2022-08-18 09:01:41

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1. A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo [J] . Ohira Makoto, Iwasaki Yuka, Tanaka Chika, Biochimica et Biophysica Acta. General Subjects . 2015,第9期

机译：具有咔唑和苯并肼结构的新型抗微管剂可抑制体内肿瘤细胞的生长
2. Gene transfer of secreted-type modified interleukin-18 gene to B16F10 melanoma cells suppresses in vivo tumor growth through inhibition of tumor vessel formation. [J] . Nagai H, Hara I, Horikawa T, The Journal of investigative dermatology. . 2002,第3期

机译：分泌型修饰的白介素18基因向B16F10黑色素瘤细胞的基因转移通过抑制肿瘤血管形成来抑制体内肿瘤的生长。
3. The TF-antigen binding lectin from Sclerotium rolfsii inhibits growth of human colon cancer cells by inducing apoptosis in vitro and suppresses tumor growth in vivo [J] . InamdarS.R., SavanurM.A., EligarS.M., Glycobiology. . 2012,第9期

机译：罗氏菌的TF-抗原结合凝集素通过诱导体外细胞凋亡抑制人结肠癌细胞的生长，并抑制体内肿瘤的生长
4. Cell death and in vivo melanoma tumor growth remission determined by a snake toxin with specificity for actively proliferating cells [C] . Sancey L., Márcia Neiva, Nascimento F.D., International Congress on Cell Biology. . 2013

机译：细胞死亡和体内黑色素瘤肿瘤生长缓解缓解蛇形测定，具有对主动增殖细胞的特异性的特异性
5. Inhibition of Lung Tumorigenesis and Cancer Cell Growth by EGCG and Other Chemopreventive Agents [D] . Jin, Huanyu. 2013

机译：EGCG和其他化学预防剂对肺肿瘤发生和癌细胞生长的抑制作用
6. Structure activity-relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N26-trimethyl-67-dihydro-5H-cyclopentadpyrimidin-4-aminium chloride and its analogues as antitumor agents [O] . Aleem Gangjee, Ying Zhao, Sudhir Raghavan, -1

机译：有效的细胞毒性抗微管剂N-（4-甲氧基苯基）-N26-三甲基-67-二氢-5H-环戊d嘧啶4的结构活性关系和体内外评价-氯化铵及其类似物作为抗肿瘤药
7. Structure–Activity Relationship and in Vitro and in Vivo Evaluation of the Potent Cytotoxic Anti-microtubule AgentN-(4-Methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopentadpyrimidin-4-aminium Chloride and Its Analogues As Antitumor Agents [O] . Aleem Gangjee, Ying Zhao, Sudhir Raghavan, 2013

机译：效力性细胞毒性抗微管 - （4-甲氧基苯基）-N，2,6-三甲基-6,7-二氢-5H-Cyclopenta D嘧啶-4-嘧啶-4-氯化氨酸和其类似物作为抗肿瘤剂

A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo

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