Cigarette smoke exposure reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR

Xu Xiaohua; Balsiger Robert; Tyrrell Jean; Boyaka Prosper N.; Tarran Robert; Cormet-Boyaka Estelle

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Cigarette smoke exposure reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR

机译：香烟烟雾暴露揭示了MEK / ERK1 / 2 MAPK途径在CFTR调节中的新作用

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Background: Cystic fibrosis transmembrane conductance regulator plays a key role in maintenance of lung fluid homeostasis. Cigarette smoke decreases CFTR expression in the lung but neither the mechanisms leading to CFTR loss, nor potential ways to prevent its loss have been identified to date.

机译：背景：囊性纤维化跨膜电导调节剂在维持肺液稳态中起着关键作用。香烟烟雾降低了肺中CFTR的表达，但迄今为止，尚未发现导致CFTR丢失的机制，也未发现防止其丢失的潜在方法。

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《Biochimica et Biophysica Acta. General Subjects》 |2015年第6期|共9页
作者
Xu Xiaohua; Balsiger Robert; Tyrrell Jean; Boyaka Prosper N.; Tarran Robert; Cormet-Boyaka Estelle;
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正文语种 eng
中图分类生物化学;
关键词
CFTR; Cigarette smoke; Airway epithelial cell; MAPK pathway;

机译：CFTR;香烟烟雾;气道上皮细胞;MAPK途径;
入库时间 2022-08-18 09:01:41

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1. Cyclosporin A通过MEK/ERK1/2信号通路调节滋养细胞titin表达 [J] . 杜美蓉, 李大金, 严缘昌, 分子细胞生物学报（英文版） . 2005,第003期
2. Cigarette smoke exposure reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR [J] . Xu Xiaohua, Balsiger Robert, Tyrrell Jean, Biochimica et Biophysica Acta. General Subjects . 2015,第6期

机译：香烟烟雾暴露揭示了MEK / ERK1 / 2 MAPK途径在CFTR调节中的新作用
3. Crosstalk between mAChRM3 and β2AR, via acetylcholine PI3/PKC/PBEP1/Raf-1 MEK1/2/ERK1/2 pathway activation, in human bronchial epithelial cells after long-term cigarette smoke exposure [J] . Giusy Daniela Albano, Anna Bonanno, Monica Moscato, Life sciences . 2018,第期

机译：MACHRM3和β2AR之间的串扰，通过乙酰胆碱PI3 / PKC / PBEP1 / RAF-1 MEK1 / 2 / ERK1 / 2途径激活，在长期卷烟烟雾暴露后的人支气管上皮细胞中
4. Alternative Roles of STAT3 and MAPK Signaling Pathways in the MMPs Activation and Progression of Lung Injury Induced by Cigarette Smoke Exposure in ACE2 Knockout Mice [J] . Yi-Han Hung, Wen-Yeh Hsieh, Jih-Sheng Hsieh, International journal of biological sciences . 2016,第4期

机译：STAT3和MAPK信号通路在ACE2敲除小鼠中香烟烟雾暴露引起的MMPs激活和肺损伤进展中的替代作用
5. Modelling of protein P2 from Haemophilus influenzae:the role of surface exposed loops on MEK1-MEK2/MAPK cascade activation [C] . Stefania Galdiero, Domenica Capasso, Mariateresa Vitiello, European Peptide Symposium . 2002

机译：嗜血杆菌蛋白P2的建模：表面暴露环对MEK1-MEK2 / MAPK级联激活的作用
6. The impact of cigarette smoke-exposure on pathways of microbial-induced pulmonary inflammation. [D] . Gaschler, Gordon J. 2009

机译：香烟烟雾暴露对微生物诱导的肺部炎症途径的影响。
7. Cigarette smoke exposure reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR [O] . Xiaohua Xu, Robert Balsiger, Jean Tyrrell, -1

机译：香烟烟雾暴露揭示了MEK / ERK1 / 2 MAPK途径在CFTR调节中的新作用
8. Cigarette smoke exposure reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR [O] . Xiaohua Xu, Robert Balsiger, Jean Tyrrell, 2015

机译：香烟烟雾曝光显示MEK / ERK1 / 2 MAPK途径在CFTR的规定中的新颖作用

Cigarette smoke exposure reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR

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