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首页> 外文期刊>Journal of applied toxicology >In vivo studies on possible adverse effects on reproduction of the fungicide methyl thiophanate.
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In vivo studies on possible adverse effects on reproduction of the fungicide methyl thiophanate.

机译：对杀真菌剂硫氰酸甲酯的繁殖可能产生不利影响的体内研究。

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摘要

The fungicide methyl thiophanate (MT), widely used to control some of the most common fungal diseases in crops, is metabolized in animals into benzimidazole compounds, including the well-known reproductive toxicant carbendazim. However, standard toxicological tests did not indicate that MT may cause testicular toxicity and/or embryotoxicity, which are typical effects of many benzimidazoles. In the present study some aspects of the MT potential for reproductive toxicity have been assayed by means of two non-conventional models. Following the oral administration of 700 and 1000 mg kg(-1) body wt. for five consecutive days, short-term testicular toxicity was examined in the B6C3F1 mouse through specific parameters (sperm head count, specific enzyme activities, histopathology on days 3-35 post-dosing). In spite of the high doses administered, none of the testicular parameters examined, including histopathology, showed significant alterations as compared to controls at any time post-dosing. Pregnant CD rat dams were administered orally the limit dose of 650 mg kg(-1) body wt. day(-1) during preimplantation (gestational day or GD 2-5) or peri-implantation (GD 6-9) phases; embryos and adnexa were evaluated morphologically on GD 12 as a window for the early observation of embryotoxicity. Evident maternal toxicity was present in both treated groups, whereas only marginal reductions of the growth of embryos and adnexa were observed. A full understanding of MT toxicology will need more quantitative data on metabolism, including plasma kinetics and dosimetry of carbendazim at the relevant targets. Nevertheless, the absence of any clear-cut effect on a number of specific endpoints may provide reassurance that no further testing of MT is needed with regard to testicular toxicity or embryotoxicity.
机译：广泛用于控制农作物中某些最常见真菌病的杀真菌剂甲基硫氰酸甲酯（MT）在动物体内代谢为苯并咪唑化合物，包括众所周知的生殖毒性多菌灵。但是，标准毒理学测试并未表明MT可能引起睾丸毒性和/或胚胎毒性，这是许多苯并咪唑的典型作用。在本研究中，已通过两种非常规模型测定了MT对生殖毒性的潜力。口服700和1000 mg kg（-1）体重后。连续五天，在B6C3F1小鼠中通过特定参数（给药后3-35天的精子头数，特定酶活性，组织病理学）检查了短期睾丸毒性。尽管给予了高剂量，但在给药后的任何时间，与对照相比，包括睾丸病理学在内的所有睾丸参数均未显示出明显的改变。口服怀孕的CD大鼠大坝的极限剂量为650 mg kg（-1）体重。植入前（妊娠日或GD 2-5）或植入前（GD 6-9）阶段的第（-1）天;胚胎和附件在GD 12上进行了形态学评估，作为早期观察胚胎毒性的窗口。在两个治疗组中均存在明显的母体毒性，而仅观察到胚胎和附件的生长略有减少。对MT毒理学的全面了解将需要更多有关代谢的定量数据，包括相关靶点的血浆动力学和多菌灵剂量学。然而，在许多特定终点上没有任何明确的影响可以保证，在睾丸毒性或胚胎毒性方面不需要进一步测试MT。

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