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首页> 外文期刊>Journal of applied toxicology >Ultrastructural changes in limb distal nerves of rats with alcoholism and/or malnutrition before and after dietary correction.
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Ultrastructural changes in limb distal nerves of rats with alcoholism and/or malnutrition before and after dietary correction.

机译：饮食校正前后酒精中毒和/或营养不良的大鼠四肢远端神经的超微结构变化。

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摘要

To study peripheral nerves changes in chronic alcoholism and in malnutrition, we examined ultrastructurally the distal nerve branches of the digits of rats treated with four different dietary schemes, as follows: controls (n = 22), fed standard rodent diet plus water ad libitum; alcoholism (n = 12), fed the standard diet and 2-12% ethanol in drinking water; malnutrition (n = 21), fed with corn tortillas instead of standard diet; and alcoholism and malnutrition combined (n = 22). After 10 months under these conditions, a proportion of animals from each group were sacrificed. The remaining rats of the malnutrition and alcoholism alone groups were deferred a standard diet. The combined alcohol + malnutrition group was subdivided into standard diet, malnutrition and ethanol. After a further 4 months under these new conditions, the animals were sacrificed. Ultrastructural examination of limb distal nerve branches showed that glycogen-like particles were more common in malnourished animals, whereas remyelinating axons were more numerous in ethanol-treated rats. Bands of regeneration were present in both groups, but were more common in animals treated with ethanol. These features decreased significantly when the respective nutritional factor was reversed. The results confirm that ethanol plays a definitive role in the development of alcoholic neuropathy and that malnutrition accentuates, the histopathological abnormalities.
机译：为了研究慢性酒精中毒和营养不良中周围神经的变化，我们用超微结构检查了用四种不同饮食方案治疗的大鼠手指的末梢神经分支，方法如下：对照组（n = 22），随意喂养标准啮齿动物饮食加水;酗酒（n = 12），进食标准饮食和饮用水中2-12％的乙醇;营养不良（n = 21），以玉米饼代替标准饮食喂养;以及酗酒和营养不良（n = 22）。在这些条件下10个月后，处死每组一定比例的动物。仅营养不良和酒精中毒组的其余大鼠被推迟标准饮食。酒精+营养不良的组合被分为标准饮食，营养不良和乙醇。在这些新条件下再过4个月后，处死动物。肢体远端神经分支的超微结构检查显示，营养不良的动物中糖原样颗粒更为常见，而用乙醇处理的大鼠中髓鞘再生轴突更多。两组均存在再生带，但在用乙醇处理的动物中更常见。当相应的营养因子被逆转时，这些特征显着降低。结果证实乙醇在酒精性神经病的发展中起着决定性的作用，营养不良加剧了组织病理学异常。

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