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首页> 外文期刊>Journal of applied toxicology >Teratological study of the herbicide 4-chloro-2-methylphenoxyacetic acid in rabbits.
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Teratological study of the herbicide 4-chloro-2-methylphenoxyacetic acid in rabbits.

机译：除草剂4-氯-2-甲基苯氧基乙酸在家兔的致畸学研究。

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摘要

4-Chloro-2-methylphenoxyacetic acid (MCPA) is an aryloxyacetic acid derivative categorised as a plant hormone herbicide. The aim of the study was to evaluate the effect of MCPA on pregnant females and the prenatal development of rabbits. The substance tested was administered orally to pregnant New Zealand White rabbits from day 6 to day 27 of gestation at doses of 5, 10 and 25 mg kg(-1) day(-1). The animals were killed on day 28 of gestation and live fetuses were examined for gross, skeletal and visceral anomalies. Administration of MPCA did not induce any signs of maternal toxicity. There was a significant decrease of fetal and placental weight compared with controls at the highest dose of MPCA. No adverse effect of the substance tested was seen on uterine content variables, e.g. corpora lutea, pre-implantation and post-implantation loss, early, late resorptions, live and dead fetuses and sex ratio. Rabbit fetuses treated with the middle and highest doses of MPCA had a significantly elevated incidenceof skull and pelvic bone delays. In conclusion, prenatal administration of MCPA did not exhibit a teratogenic effect on rabbit fetus development.
机译：4-氯-2-甲基苯氧基乙酸（MCPA）是一种被分类为植物激素除草剂的芳氧基乙酸衍生物。该研究的目的是评估MCPA对怀孕雌性和兔子产前发育的影响。从妊娠的第6天到第27天，将受试物质口服给予怀孕的新西兰白兔，剂量为5、10和25 mg kg（-1）day（-1）。在妊娠的第28天将动物处死，并检查活胎儿的总体，骨骼和内脏异常。施用MPCA不会引起任何母体毒性迹象。与MPCA最高剂量的对照组相比，胎儿和胎盘重量显着降低。没有观察到所测试物质对子宫内含物变量的不利影响。黄体，着床前和着床后丢失，早期，晚期吸收，活着和死去的胎儿以及性别比。用中等剂量和最高剂量的MPCA处理的兔胎儿颅骨和骨盆骨延迟的发生率显着升高。总之，产前服用MCPA对兔子胎儿的发育没有致畸作用。

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