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首页> 外文期刊>Journal of applied toxicology >The influence of curcumin and manganese complex of curcumin on cadmium-induced oxidative damage and trace elements status in tissues of mice.
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The influence of curcumin and manganese complex of curcumin on cadmium-induced oxidative damage and trace elements status in tissues of mice.

机译：姜黄素和姜黄素的锰复合物对镉诱导的小鼠组织氧化损伤和微量元素状态的影响。

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Curcumin (diferuoyl methane) from turmeric is a well-known biologically active compound. It has been shown to ameliorate oxidative stress and it is considered to be a potent cancer chemopreventive agent. In our previous study the antioxidative effects of curcumin in cadmium exposed animals were demonstrated. Also manganese exerts protective effects in experimental cadmium intoxication. The present study examined the ability of the manganese complex of curcumin (Mn-curcumin) and curcumin to protect against oxidative damage and changes in trace element status in cadmium-intoxicated male mice. Curcumin or Mn-curcumin were administered at equimolar doses (0.14 mmol/kg b.w.) for 3 days, by gastric gavages, dispersed in methylcellulose. One hour after the last dose of antioxidants, cadmium chloride (33 micromol/kg) was administered subcutaneously. Both curcumin and Mn-curcumin prevented the increase of hepatic lipid peroxidation -- expressed as MDA level, induced by cadmium intoxication and attenuated the Cd-induced decrease of hepatic GSH level. No change in hepatic glutathione peroxidase or catalase activities was found in Cd-exposed mice. A decreased GSH-Px activity was measured in curcumin and Mn-curcumin alone treated mice. Neither curcumin nor Mn-curcumin treatment influenced cadmium distribution in the tissues and did not correct the changes in the balance of essential elements caused by Cd-treatment. The treatment with Mn-curcumin increased the Fe and Mn content in the kidneys of both control and Cd-treated mice and Fe and Cu content in the brain of control mice. In conclusion, regarding the antioxidative action, introducing manganese into the curcumin molecule does not potentiate the studied effects of curcumin.
机译：姜黄的姜黄素（二氟甲酰甲烷）是众所周知的生物活性化合物。已经表明它可以减轻氧化应激，并且被认为是有效的癌症化学预防剂。在我们先前的研究中，姜黄素对暴露于镉的动物具有抗氧化作用。锰还对实验性镉中毒起到保护作用。本研究检查了姜黄素（Mn-姜黄素）和姜黄素的锰复合物对氧化毒性和镉中毒雄性小鼠体内微量元素状态变化的保护能力。姜黄素或锰姜黄素以等摩尔剂量（0.14 mmol / kg b.w.）连续3天通过胃管灌胃，并分散在甲基纤维素中。最后一剂抗氧化剂一小时后，皮下注射氯化镉（33微摩尔/千克）。姜黄素和锰姜黄素均阻止了由镉中毒引起的肝脂质过氧化的增加-表示为MDA水平，并减轻了Cd诱导的肝GSH水平的降低。在镉暴露的小鼠中未发现肝谷胱甘肽过氧化物酶或过氧化氢酶活性发生变化。在单独用姜黄素和Mn-姜黄素治疗的小鼠中测得GSH-Px活性降低。姜黄素和锰姜黄素都没有影响镉在组织中的分布，也没有纠正镉处理引起的必需元素平衡的变化。锰姜黄素治疗可增加对照和Cd处理小鼠肾脏中的Fe和Mn含量，以及对照小鼠大脑中的Fe和Cu含量。总之，关于抗氧化作用，将锰引入姜黄素分子并不能增强对姜黄素的研究效果。

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