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首页> 外文期刊>Journal of applied toxicology >Toxicogenomics: a pivotal piece in the puzzle of toxicological research.
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Toxicogenomics: a pivotal piece in the puzzle of toxicological research.

机译：毒理基因组学：毒理学研究难题中的关键部分。

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摘要

Toxicogenomics, resulting from the merge of conventional toxicology with functional genomics, being the scientific field studying the complex interactions between the cellular genome, toxic agents in the environment, organ dysfunction and disease state. When an organism is exposed to a toxic agent the cells respond by altering the pattern of gene expression. Genes are transcribed into mRNA, which in turn is translated into proteins that serve in a variety of cellular functions. Toxicogenomics through microarray technology, offers large-scale detection and quantification of mRNA transcripts, related to alterations in mRNA stability or gene regulation. This may prove advantageous in toxicological research. In the present review, the applications of toxicogenomics, especially to mechanistic and predictive toxicology are reported. The limitations arising from the use of this technology are also discussed. Additionally, a brief report of other approaches, using other -omic technologies (proteomics and metabonomics) that overcome limitations and give global information related to toxicity, is included.
机译：毒理基因组学是传统毒理学与功能基因组学的结合，是研究细胞基因组，环境中有毒物质，器官功能障碍和疾病状态之间复杂相互作用的科学领域。当有机体暴露于有毒物质时，细胞会通过改变基因表达方式做出反应。基因被转录成mRNA，而后者又被翻译成具有多种细胞功能的蛋白质。通过微阵列技术进行的毒理基因组学可对mRNA转录物进行大规模检测和定量，与mRNA稳定性或基因调控的改变有关。这可能在毒理学研究中被证明是有利的。在本综述中，报道了毒物基因组学的应用，特别是在机理和预测毒理学上的应用。还讨论了使用该技术引起的局限性。此外，还包括使用其他组学技术（蛋白质组学和代谢组学）克服了局限性并提供了与毒性有关的全局信息的其他方法的简短报告。

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