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首页> 外文期刊>Journal of applied toxicology >Urinary excretion of toluene diisocyanates in rats following dermal exposure.
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Urinary excretion of toluene diisocyanates in rats following dermal exposure.

机译：皮肤暴露后大鼠尿中甲苯二异氰酸酯的排泄。

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Toluene diisocyanates (TDI) are commonly used in polyurethane (PU)-related products. TDIs have been documented as the leading cause of occupational asthma. Skin exposure to TDI in the workplace is common. However, no studies in the literature have investigated the exact biomarker concentration profile for skin TDI absorption through any in vivo animal studies. In this study a rat model was used to evaluate the TDI skin absorption to explore the dose-response pattern and to determine the kinetic characteristics of urinary toluene diamine (U-TDA) during skin exposure. TDIs were topically exposed on the dorsum of rat skin at 0.2%, 1% and 5%. Consecutive urine samples were collected for 6 days and U-TDA were analysed using GC/ECD. It was demonstrated in this rat study that absorption of 2,4- and 2,6-TDI through skin contact is possible. A clear dose-dependent skin absorption relationship for 2,4- and 2,6-TDI was demonstrated by the AUC, Cmax findings and accumulative amounts (r > or = 0.968). U-TDA concentration profiles in 6-day consecutive urine samples fit well in the first-order kinetics, although higher order kinetics could not be excluded for the high dose. The apparent half-lives for excretory urinary TDA were about 20 h consistent at various skin exposures. It is concluded that skin absorption of TDI was confirmed in a rat model and a clear dose-dependent skin absorption relationship for 2,4- and 2,6-TDI was demonstrated. Excretory U-TDA concentrations in 6-day consecutive urine samples via skin exposure reveal the first-order kinetics and the half-lives were about 20 h.
机译：甲苯二异氰酸酯（TDI）通常用于聚氨酯（PU）相关产品。 TDI已被证明是职业性哮喘的主要原因。在工作场所皮肤接触TDI很常见。但是，没有文献研究通过任何体内动物研究来研究皮肤TDI吸收的确切生物标志物浓度曲线。在这项研究中，使用大鼠模型评估TDI皮肤吸收量，以探索剂量反应模式并确定皮肤暴露期间尿甲苯二胺（U-TDA）的动力学特征。 TDI以0.2％，1％和5％局部暴露于大鼠皮肤的背部。连续6天收集尿液样本，并使用GC / ECD分析U-TDA。在该大鼠研究中证明，可以通过皮肤接触吸收2,4-和2,6-TDI。通过AUC，Cmax结果和累积量（r>或= 0.968）证明了2,4-和2,6-TDI的明显的剂量依赖性皮肤吸收关系。连续6天尿液样本中的U-TDA浓度曲线非常适合一级动力学，尽管高剂量不能排除较高级动力学。在各种皮肤暴露下，排泄性尿TDA的表观半衰期约为20小时。结论是，在大鼠模型中证实了TDI的皮肤吸收，并且证明了2，4-和2，6-TDI的明显的剂量依赖性皮肤吸收关系。通过皮肤暴露连续六天尿液样本中的排泄性U-TDA浓度显示一级动力学，半衰期约为20小时。

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