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首页> 外文期刊>Journal of applied toxicology >Resveratrol and trimethylated resveratrol protect from acute liver damage induced by CCl4 in the rat.
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Resveratrol and trimethylated resveratrol protect from acute liver damage induced by CCl4 in the rat.

机译：白藜芦醇和三甲基化白藜芦醇可保护大鼠免受CCl4诱导的急性肝损伤。

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The importance of hydroxyl groups in the antioxidant and hepatoprotective properties of resveratrol was investigated. To achieve this, resveratrol or its trimethylated analog were administered (10 mg kg(-1), p.o.) to male Wistar rats and liver damage was induced by acute administration of CCl4 (4 g kg(-1), p.o.); appropriate controls were performed. The animals were killed 24 h after CCl4 intoxication. The amount of reduced glutathione (GSH) in the liver was not modified by any treatment; interestingly, the GSH/GSSG (oxidized glutathione) ratio decreased in the groups receiving CCl4 and resveratrol associated with an increase in GSSG. In blood GSH and the GSH/GSSG ratio were decreased by CCl4; both effects were completely prevented by any of the compounds tested. Lipid peroxidation and the activity of gamma-glutamyl transpeptidase were increased significantly after CCl4. Resveratrol partially prevented these increases and surprisingly, trimethylated resveratrol completely prevented the increase of these markers. Both compounds partially but significantly prevented the increase in the activity of alanine aminotransferase; this result agrees with observations in the histological analysis. Both tested compounds administered alone produced no effect. The results of the present study suggest that OH groups are important for the antioxidant and hepatoprotective properties of the molecule of resveratrol; nevertheless, these effects can be improved by replacing hydrogen by a methyl in these groups. The differences in the antioxidant and hepatoprotective effects of these compounds could be due to the possibility that the trimethylated resveratrol acts like a prodrug, prolonging, probably, the half-life of the original compound.
机译：研究了羟基在白藜芦醇的抗氧化剂和肝保护特性中的重要性。为此，向雄性Wistar大鼠服用白藜芦醇或其三甲基化类似物（10 mg kg（-1），p.o。），并通过急性给予CCl4（4 g kg（-1），p.o。）诱导肝损害。进行适当的控制。 CCl4中毒后24小时将动物处死。肝脏中还原型谷胱甘肽（GSH）的量未通过任何治疗改变;有趣的是，接受CCl4和白藜芦醇的组中的GSH / GSSG（氧化型谷胱甘肽）比率降低，这与GSSG的增加有关。 CCl4降低了血液中的GSH和GSH / GSSG比;两种测试化合物均可完全防止这两种作用。 CCl4处理后，脂质过氧化和γ-谷氨酰转肽酶的活性显着增加。白藜芦醇部分地阻止了这些增加，并且令人惊讶地，三甲基化白藜芦醇完全阻止了这些标志物的增加。两种化合物均部分但显着地阻止了丙氨酸氨基转移酶活性的增加。该结果与组织学分析中的观察结果一致。单独施用的两种测试化合物均未产生作用。本研究的结果表明，OH基对于白藜芦醇分子的抗氧化和保肝性能很重要。但是，可以通过在这些基团中用甲基取代氢来改善这些效果。这些化合物的抗氧化剂和肝保护作用的差异可能是由于三甲基化白藜芦醇有可能像前药一样起作用，从而可能延长了原始化合物的半衰期。

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