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首页> 外文期刊>Journal of applied toxicology >Anticoagulant effect of sodium dehydroacetate (DHA-S) in rats.
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Anticoagulant effect of sodium dehydroacetate (DHA-S) in rats.

机译：脱氢乙酸钠（DHA-S）在大鼠中的抗凝作用。

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摘要

Sodium dehydroacetate (DHA-S) is used as a food additive, preservative and antimicrobial agent. Repeated oral administration of DHA-S in rats induced severe hemorrhage in multiple organs and prolongation of blood coagulation factors. To determine the mechanism of hemorrhage, the protective effect of vitamin K (VK) was investigated. Increased VK-dependent blood coagulation parameters, a prolonged prothrombin time (PT) and an activated partial thromboplastin time (APTT) were observed in rats when DHA-S alone was administered, while only a slight change was observed in animals that received a single injection of vitamin K2 following the DHA-S dosing. These results suggest that DHA-S-induced hemorrhage is caused by a deficiency of vitamin K. In addition, the inhibitory effect of DHA-S on vitamin K1 epoxide reductase (VKOR) activity was measured with an in vitro system using liver microsomes of normal male rats. DHA-S concentration-dependently inhibited VKOR activity similar to warfarin, but the inhibitory concentration was high. Therefore, it was concluded that the DHA-S-induced hemorrhage was caused by a depletion of blood VK, associated with any factors including VKOR inhibition.
机译：脱氢乙酸钠（DHA-S）用作食品添加剂，防腐剂和抗菌剂。在大鼠中反复口服DHA-S会导致多器官严重出血和凝血因子延长。为了确定出血的机理，研究了维生素K（VK）的保护作用。单独给予DHA-S的大鼠观察到VK依赖的凝血参数增加，凝血酶原时间（PT）延长和凝血活酶部分时间激活（APTT），而单次注射的动物仅观察到轻微变化DHA-S给药后补充维生素K2。这些结果表明，DHA-S引起的出血是由于维生素K缺乏引起的。此外，使用体外正常肝细胞微粒体的体外系统测定了DHA-S对维生素K1环氧还原酶（VKOR）活性的抑制作用。雄性大鼠。与华法林类似，DHA-S浓度依赖性地抑制VKOR活性，但抑制浓度较高。因此，可以得出结论，DHA-S引起的出血是由血液VK消耗引起的，与包括VKOR抑制在内的任何因素有关。

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