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首页> 外文期刊>Journal of applied toxicology >Assessment of hair and bone accumulation of beryllium by mice exposed to contaminated dusts.
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Assessment of hair and bone accumulation of beryllium by mice exposed to contaminated dusts.

机译：暴露于受污染粉尘的小鼠对铍的头发和骨积累的评估。

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This study looks at the accumulation of Be in the hair and bones of mice to understand both the use of hair as a bioindicator of exposure to Be and accumulation in bones as a means to evaluate the translocation of Be. We exposed two groups of mice (C3H/HeJ) to 250 microg m(-3) of two different particles sizes of Be metal (fine and intermediate; Be-F and Be-I) during 3 weeks of nose-only inhalation exposure. A control group was exposed to HEPA-filtered air. Mice were sacrificed either 1 or 3 weeks after the end of exposure. Mice were shaved and the bones were extracted. For washed hair, the results of mice sacrificed one week after the end of exposure were 8.3 + or - 1.4 microg kg(-1) hair for the control group, 114 + or - 42 microg kg(-1 )hair for the Be-I group, and 159 + or - 65 microg kg(-1) hair for the Be-F group. Results for Be-F mice sacrificed 3 weeks after the end of exposure showed an average Be concentration in washed hair of 419 + or - 100 microg kg(-1), thus suggesting that excretion of Be in hair increases with time. Be concentration in bones was 6 + or - 3 microg kg(-1) dry bone tissues for the control group, compared with 24 + or - 7 microg kg(-1) for Be-I and 34 + or - 6 or 43 + or - 8 microg kg(-1) for Be-F in mice sacrificed 1 or 3 weeks after the end of exposure. These results demonstrate the potential of using hair and bone as bioindicators of Be exposure.
机译：这项研究着眼于小鼠头发和骨骼中Be的积累，以了解使用头发作为暴露于Be的生物指标以及骨骼中积累以评估Be易位的方法。在仅鼻吸入暴露的3周中，我们将两组小鼠（C3H / HeJ）暴露于250 microg m（-3）的两种不同粒径的Be金属（精细和中等; Be-F和Be-I）。对照组暴露于经过HEPA过滤的空气中。暴露结束后1或3周处死小鼠。将小鼠剃毛并取出骨头。对于洗过的头发，暴露结束后一周处死的小鼠的结果是，对照组为8.3 +或-1.4 microg kg（-1）头发，对于Be-为114 +或-42 microg kg（-1）头发I组，Be-F组为159 +或-65 microg kg（-1）头发。在暴露结束后3周处死的Be-F小鼠的结果显示，洗过的头发中的平均Be浓度为419 +或-100 microg kg（-1），因此表明随着时间的推移，头发中Be的排泄量增加。对照组的骨骼中Be浓度为6 +或-3 microg kg（-1）干燥骨组织，而Be-I和Be-I为34 +或-7 microg kg（-1）和-6或43 +或-暴露结束1或3周后处死的Be-F小鼠为8 microg kg（-1）。这些结果证明了使用头发和骨骼作为Be暴露生物指标的潜力。

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