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首页> 外文期刊>Journal of applied toxicology >Conservation of the chromatophore pigment response.
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Conservation of the chromatophore pigment response.

机译:保留了色谱色素反应。

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摘要

Toxicant sensing technology has evolved to include biological sensors, such as cell-based biosensors, which rely on viable cells to convey a measurable physiological signal. Chromatophores are a class of pigment cells that have been investigated as cell-based biosensors. We report the characterization of Oncorhynchus tshawytscha melanophores and describe the melanophore pigment response to neurotransmitters in terms of pigment area occupied. Compared with the previously described model, Betta splendens erythrophores, O. tshawytscha melanophores responded similarly, indicating that pigment responses are biologically conserved between these two species. Additionally, melanophores responded to mercuric chloride and sodium arsenite, similar to B. splendens erythrophores, suggesting that melanophores can be used as detectors for environmental toxicants. This report highlights the potential of O. tshawytscha melanophores to be used as cell-based biosensors to address environmental toxicity, and warrants a continued investigation to strengthen this technology and its applications.
机译:毒物感测技术已经发展为包括生物传感器,例如基于细胞的生物传感器,该传感器依靠活细胞来传递可测量的生理信号。染色体是一类色素细胞,已被研究为基于细胞的生物传感器。我们报告了Oncorhynchus tshawytscha黑色素细胞的表征,并描述了色素沉着对神经递质的色素沉着反应。与先前描述的模型相比,Betta splendens erythrophores,O。tshawytscha melanophores的响应相似,表明这两种物种之间的色素反应在生物学上是保守的。另外,类似于闪闪发光的B. splendens erythrophores,黑色素细胞对氯化汞和亚砷酸钠有反应,这表明黑色素细胞可以用作环境有毒物质的检测器。本报告强调了O. tshawytscha melanophores可用作基于细胞的生物传感器以解决环境毒性的潜力,并有必要进行持续研究以增强该技术及其应用。

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