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首页> 外文期刊>Journal of applied toxicology >Biocompatible gellan gum-reduced gold nanoparticles: cellular uptake and subacute oral toxicity studies
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Biocompatible gellan gum-reduced gold nanoparticles: cellular uptake and subacute oral toxicity studies

机译：生物相容性结冷胶还原的金纳米颗粒：细胞摄取和亚急性口服毒性研究

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摘要

Currently gold nanoparticles are being explored for drug delivery and other biomedical applications; therefore it is necessary to study the fate of such nanoparticles inside the body. The objective of the present study was to investigate the cellular uptake and toxicity of the gold nanoparticles synthesized using a microbial polysaccharide, gellan gum, as a capping and reducing agent. The cellular uptake of gold nanoparticles was studied on mouse embryonic fibroblast cells, NIH3T3 and human glioma cell line, LN-229. The cellular uptake study indicated that the gellan gum-reduced gold nanoparticles were located in cancer cells (LN-229) while no uptake was observed in normal mouse embryonic fibroblast cells (NIH3T3). The toxicity of the gold nanoparticles was evaluated by carrying out subacute 28 day oral toxicity studies in rats. Subacute administration of gum-reduced gold nanoparticles to the rats did not show any hematological or biochemical abnormalities. The weight and normal architecture of various organs did not change compared with control. The current findings, while establishing the specific uptake of nanoparticles into cancerous cells, also demonstrates that the gellan gum-reduced gold nanoparticles are devoid of toxicity in animals following oral administration.
机译：目前，正在研究金纳米颗粒用于药物递送和其他生物医学应用。因此有必要研究这类纳米粒子在人体内的命运。本研究的目的是研究使用微生物多糖结冷胶作为封闭剂和还原剂合成的金纳米颗粒的细胞吸收和毒性。在小鼠胚胎成纤维细胞NIH3T3和人神经胶质瘤细胞系LN-229上研究了金纳米颗粒的细胞摄取。细胞摄取研究表明，结冷胶还原的金纳米颗粒位于癌细胞（LN-229）中，而在正常小鼠胚胎成纤维细胞（NIH3T3）中未观察到摄取。通过在大鼠中进行亚急性28天口服毒性研究，评估了金纳米颗粒的毒性。对大鼠亚急性减胶的金纳米颗粒的给药未显示任何血液学或生化异常。与对照相比，各个器官的重量和正常结构没有变化。目前的发现，尽管确定了纳米颗粒对癌细胞的特异性摄取，但也表明，经结冷胶还原的金纳米颗粒在口服后对动物没有毒性。

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