Preclinical risk assessment of drug-induced hypo- and hyperprolactinemia.

Hargreaves A; Harleman J

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Preclinical risk assessment of drug-induced hypo- and hyperprolactinemia.

机译：药物诱发的低泌乳素血症和高泌乳素血症的临床前风险评估。

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Drug-induced changes in prolactin signaling may obscure interpretation of preclinical toxicological endpoints. However, with informed consideration, classic hallmarks of hypo-/hyperprolactinemia can be recognized in short- and long-term rodent bioassays. Findings can be supported and expanded with additional in vivo and in vitro datasets. When taken together with human epidemiological evidence pertaining to the consequences of drug-induced hypo-/hyperprolactinemia, such findings permit both an analysis of human relevance and an assessment of human risk.

机译：催乳素信号传导中的药物诱导的变化可能会模糊临床前毒理学终点的解释。然而，经过充分考虑，低/高催乳素血症的经典标志可以在短期和长期的啮齿动物生物测定中得到认可。研究结果可以通过其他体内和体外数据集得到支持和扩展。当与有关药物引起的低/高催乳素血症后果的人类流行病学证据一起使用时，这些发现既可以分析人类相关性，也可以评估人类风险。

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《Journal of applied toxicology》 |2011年第7期|共9页
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Hargreaves A; Harleman J;
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中图分类毒物学（毒理学）;
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1. Preclinical risk assessment of drug-induced hypo- and hyperprolactinemia. [J] . Hargreaves A, Harleman J Journal of applied toxicology . 2011,第7期

机译：药物诱发的低泌乳素血症和高泌乳素血症的临床前风险评估。
2. Human stem cell-derived hepatocytes: Breakthrough of an expedient tool for preclinical assessment of drug-induced liver injury? [J] . M.RodriguesR., DeKockJ. Archives of Toxicology . 2014,第2期

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3. Preclinical assessment of drug-induced proarrhythmia in arterially perfused rabbit left ventricular wedge preparations: An important role for stimulation rates [J] . Lu Hua Rong, Gallacher David J., Yan Gan-Xin Journal of Pharmacological and Toxicological Methods . 2014,第3期

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Preclinical risk assessment of drug-induced hypo- and hyperprolactinemia.

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