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首页> 外文期刊>Journal of applied toxicology >Toxicity studies of nonylphenol and octylphenol: hormonal, hematological and biochemical effects in Clarias gariepinus.
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Toxicity studies of nonylphenol and octylphenol: hormonal, hematological and biochemical effects in Clarias gariepinus.

机译：壬基苯酚和辛基苯酚的毒性研究：刺槐中的激素，血液学和生化作用。

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摘要

Among the numerous chemicals discharged into aquatic ecosystems, nonylphenol (NP) and octylphenol (OP) have been shown to have a potent effect on the endocrine system of fish; this issue has been clearly dealt with in several studies. The objective of this study was to assess and compare the general toxicity of these estrogenic chemicals individually on Clarias gariepinus. Fish were exposed to different concentrations of both NP and OP (250, 500, 750 and 1000 mug l(-1) ) under semi-static conditions for a period of 7 days. The adverse effect was evaluated with use of blood cell counting, hemoglobin (Hb), hematocrit (HCT), hematimetric indices, bilirubin, protein, glucose, serum transaminases, serum phosphatases, lactate dehydrogenase and cortisol. The results showed a clear indication of anemia, increases in leukocyte count and bilirubin content and a reduction in plasma protein levels with higher concentrations of both the toxicants compared with controls. Furthermore, with all the concentrations the inevitable increase in serum cortisol and plasma glucose showed primary and secondary stress responses. Moreover, probable tissue damage gave rise to a series of fluctuations of enzyme levels at lower concentrations, but a decrease with higher concentrations showed the severity of the effect. Depending on the parameters examined, OP had a relatively greater effect than NP. Overall, these two chemicals seemingly affected hematology and the activity of some enzymes, leading to serious impairment of the metabolism and physiology of C. gariepinus. Copyright (c) 2011 John Wiley & Sons, Ltd.
机译：在排放到水生生态系统中的多种化学物质中，壬基酚（NP）和辛基酚（OP）已显示对鱼类的内分泌系统具有有效作用;在一些研究中已经清楚地解决了这个问题。这项研究的目的是评估和比较这些雌激素化学物质对on草的总体毒性。在半静态条件下，将鱼暴露于不同浓度的NP和OP（250、500、750和1000杯l（-1））中，持续7天。使用血细胞计数，血红蛋白（Hb），血细胞比容（HCT），血细胞指数，胆红素，蛋白质，葡萄糖，血清转氨酶，血清磷酸酶，乳酸脱氢酶和皮质醇评估不良反应。结果表明，与对照组相比，两种毒物的浓度都更高，表明贫血，白细胞计数和胆红素含量增加，血浆蛋白水平降低明显。此外，在所有浓度下，血清皮质醇和血浆葡萄糖不可避免地增加，显示出初级和次级应激反应。而且，可能的组织损伤在较低浓度下会引起一系列酶水平的波动，但是在较高浓度下的下降表明这种作用的严重性。根据所检查的参数，OP比NP具有相对更大的作用。总体而言，这两种化学物质似乎影响了血液学和某些酶的活性，导致加里氏梭菌的代谢和生理严重受损。版权所有（c）2011 John Wiley＆Sons，Ltd.

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