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首页> 外文期刊>Journal of applied toxicology >Proteomic analysis of the differentially expressed proteins by airborne nanoparticles
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Proteomic analysis of the differentially expressed proteins by airborne nanoparticles

机译：机载纳米颗粒差异表达蛋白质的蛋白质组学分析

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Airborne nanoparticles with thermodynamic diameters less than 56 nm (PMo.os6) were collected using a Moudi cascade impactor, and the differentially expressed proteins upon exposure to the airborne nanoparticles were identified in human bronchial epithelial cells. More than 600 protein spots were detected on the two-dimensional gel, and the identified 13 of these proteins showed notable changes. Nine were up-regulated and four were down-regulated following treatment with the airborne nanoparticles. Notably, malignant transformation-associated multiple forms of keratins, epigenetic regulation-related MBD1-containing chromatin associated factor 2, epithelial malignancy-related vimentin and exocytosis-related annexin A2 were changed upon exposure to airborne nanoparticle PM0.056.
机译：使用Moudi级联撞击器收集热力学直径小于56 nm的机载纳米颗粒（PMo.os6），并在人支气管上皮细胞中鉴定出暴露于机载纳米颗粒后差异表达的蛋白质。在二维凝胶上检测到600多个蛋白质斑点，其中鉴定出的13种蛋白质显示出显着变化。机载纳米粒子处理后，有9个上调，有4个下调。值得注意的是，暴露于空气中的纳米颗粒PM0.056后，恶性转化相关的多种形式的角蛋白，表观遗传调控相关的含MBD1的染色质相关因子2，上皮恶性相关的波形蛋白和胞吐相关的膜联蛋白A2发生了变化。

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