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首页> 外文期刊>Journal of applied toxicology >Ghrelin and toxicity: Recent findings and future challenges
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Ghrelin and toxicity: Recent findings and future challenges

机译：生长激素释放肽和毒性：最新发现和未来挑战

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摘要

Ghrelin is a novel brain-gut peptide that plays various roles in mammals, including control of food intake and growth hormone release, as well as gastric motility and acid secretion in the gastrointestinal tract. It is mainly secreted by the gastric mucosa, but is also expressed in various other tissues. Different studies confirm the multiple biological roles of and possible protective effects of ghrelin. Multiple in vitro and in vivo studies support the powerful protective action of ghrelin against heart, gastric and liver injury. Moreover, ghrelin has been reported to be beneficial in renal tissue injury and excretory function after ischemia-reperfusion and to exert neuroprotective effects in cerebral ischemic regions. The aim of this review is to summarize and evaluate all the currently available in vivo and in vitro studies regarding the effects of ghrelin on tissue injury induced in different organs and tissues.
机译：Ghrelin是一种新型的脑肠肽，在哺乳动物中起着各种作用，包括控制食物的摄取和生长激素的释放，以及胃肠道的胃动力和胃酸分泌。它主要由胃粘膜分泌，但也可以在多种其他组织中表达。不同的研究证实了生长素释放肽的多种生物学作用以及可能的保护作用。多项体外和体内研究支持生长素释放肽对心脏，胃和肝损伤的强大保护作用。此外，据报道生长素释放肽对缺血-再灌注后的肾组织损伤和排泄功能有益，并在脑缺血区域发挥神经保护作用。这篇综述的目的是总结和评估关于生长素释放肽对不同器官和组织引起的组织损伤的影响的所有现有的体内和体外研究。

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