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首页> 外文期刊>Journal of applied toxicology >Gestational administration of cadmium alters the neurotransmitter levels in newborn rat brains.
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Gestational administration of cadmium alters the neurotransmitter levels in newborn rat brains.

机译：镉的妊娠管理改变了新生大鼠大脑中的神经递质水平。

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摘要

The effects of gestational and early lactational intoxication by cadmium (Cd) were studied in the brain of young Wistar rats. Pregnant rats were exposed to 10 mg of cadmium acetate per litre of drinking water, from initiation of pregnancy to parturition or until postnatal day 5. At birth or on postnatal day (PND) 5 the pups were weighed, sacrificed and brains were removed and frozen for later study. Protein, lipid and nucleic acid contents were measured and the brain Cd concentration was determined. Levels of dopamine (DA), 5-hydroxytryptamine (5-HT) and their respective metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) were measured in neonatal pup brain by higher performance liquid chromatography with electrochemical detection. The results from this experiment showed that Cd increased the 5-HT and 5-HIAA contents in all areas of the brain and the DA and DOPAC levels in mesencephalon, but decreased the DA and DOPAC levels in the metencephalon. On the other hand, Cd intoxication did not modify the other biochemical parameters measured, with the exception of a decrease in nucleic acids on PND 5.
机译：在年轻的Wistar大鼠的大脑中研究了镉（Cd）对妊娠和哺乳早期中毒的影响。从怀孕开始至分娩或直到出生后第5天，怀孕的大鼠每公升饮用水中暴露10 mg乙酸镉，在出生或出生后第5天（PND），将幼犬称重，处死，取出大脑并冷冻供以后学习。测量蛋白质，脂质和核酸含量，并确定脑中镉的浓度。用高效液相色谱法测定新生幼鼠脑中多巴胺（DA），5-羟色胺（5-HT）及其代谢产物3,4-二羟苯乙酸（DOPAC）和5-羟吲哚乙酸（5-HIAA）的水平。电化学检测。该实验的结果表明，Cd增加了大脑所有区域的5-HT和5-HIAA含量以及中脑的DA和DOPAC水平，但降低了中脑的DA和DOPAC水平。另一方面，镉中毒不会改变测得的其他生化参数，但PND 5上的核酸减少除外。

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