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首页> 外文期刊>Journal of applied toxicology >Investigations on the in vitro and in vivo genotoxic potential of 5-vinyl-2-norbornene.
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Investigations on the in vitro and in vivo genotoxic potential of 5-vinyl-2-norbornene.

机译：5-乙烯基-2-降冰片烯的体外和体内遗传毒性潜力研究。

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摘要

5-Vinyl-2-norbornene (VNB: CAS no. 3048-64-4), an industrial chemical that produces hyaline droplet nephropathy in the male rat with associated alpha2u-globulin increases, was investigated in vitro and in vivo for its genotoxic potential. A Salmonella typhimurium reverse mutation assay (strains TA98, 100, 1535, 1537, 1538) was negative both without (dose range 0.003-0.3 mg per plate) and with (0.003-0.3 mg per plate) metabolic activation. A forward gene mutation test in Chinese Hamster Ovary (CHO) cells (HGPRT locus) did not show any significant concentration-related increases in mutation frequencies in the absence (0.01-0.1 mg ml[-1]) or presence (0.005-0.1 mg ml[-1]) of metabolic activation. In a sister chromatid exchange (SCE) test, VNB did not produce statistically significant or dose-related increases in the incidence of SCEs in the absence (0.02-0.06 mg ml[-1]) or presence (0.005-0.03 mg ml[-1]) of metabolic activation. A bone marrow chromosome aberration test was conducted in groups of 10 male and 10 female Sprague-Dawley rats exposed for 6 hr/day for 5 consecutive days to mean (+/- SD) VNB vapor concentrations of 0 (air control), 48.1 +/- 1.29, 146 +/- 9.2, or 336 +/- 8.5 ppm. Marrow was collected 6 and 24 hr after the final exposure. No statistically significant or dose-related increases in chromosomal aberrations occurred in the VNB-exposed animals. 5-Vinyl-2-norbornene did not show any potential for genotoxic activity with this in vitro-in vivo battery of tests.
机译：5-Vinyl-2-降冰片烯（VNB：CAS No.3048-64-4）是一种在雄性大鼠中产生透明液滴性肾病并伴有α2u-球蛋白增加的工业化学品，已在体内和体外研究了其遗传毒性潜力。沙门氏菌鼠伤寒沙门氏菌反向突变试验（菌株TA98、100、1535、1537、1538）在没有（每板剂量范围0.003-0.3 mg）和有（每板0.003-0.3 mg）代谢激活的情况下均为阴性。在中国仓鼠卵巢（CHO）细胞（HGPRT基因座）上进行的正向基因突变测试未显示在不存在（0.01-0.1 mg ml [-1]）或存在（0.005-0.1 mg）的情况下，突变频率与浓度相关的显着增加ml [-1]）的代谢活化。在姐妹染色单体交换（SCE）测试中，在不存在（0.02-0.06 mg ml [-1]）或存在（0.005-0.03 mg ml [-]的情况下，VNB均未产生统计学上显着或剂量相关的SCE发生率增加1]）的代谢活化。在10只雄性和10只雌性Sprague-Dawley大鼠的组中进行了骨髓染色体畸变测试，每天连续6天每天暴露6个小时，其平均（+/- SD）VNB蒸气浓度为0（空气控制），为48.1 + /-1.29、146 +/- 9.2或336 +/- 8.5 ppm。最后一次暴露后6小时和24小时收集骨髓。在暴露于VNB的动物中，染色体畸变没有统计学上显着或剂量相关的增加。 5-Vinyl-2-降冰片烯没有显示出任何潜在的遗传毒性活性。

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