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首页> 外文期刊>Journal of applied toxicology >Rhein affects arylamine N-acetyltransferase activity in Helicobacter pylori from peptic ulcer patients.
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Rhein affects arylamine N-acetyltransferase activity in Helicobacter pylori from peptic ulcer patients.

机译：大黄酸影响消化性溃疡患者幽门螺杆菌中的芳胺N-乙酰基转移酶活性。

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摘要

Arylamine N-acetyltransferase (NAT) activities with 2-aminofluorene and p-aminobenzoic acid were determined in the bacterium Helicobacter pylori collected from peptic ulcer patients. Cytosols or suspensions of H. pylori with or without specific concentrations of rhein co-treatment showed different percentages of 2-aminofluorene and p-aminobenzoic acid acetylation. The data indicate that there was decreased NAT activity associated with increased levels of rhein in H. pylori cytosols. Inhibition of growth studies from H. pylori demonstrated that rhein elicited dose-dependent bacteriostatic activity in H. pylori cultures: i.e. the greater the concentration of rhein, the greater the inhibition of growth to H. pylori. For the cytosol and intact bacteria examination, the apparent values of Km and Vmax were decreased after co-treatment with 40 microM rhein. This report is the first demonstration of rhein inhibition of arylamine N-acetyltransferase activity and rhein inhibition of growth in the bacterium H. pylori.
机译：在从消化性溃疡患者收集的幽门螺杆菌中测定了2-氨基芴和对氨基苯甲酸的芳胺N-乙酰基转移酶（NAT）活性。带有或不带有特定浓度的大黄酸共同处理的幽门螺杆菌的细胞溶胶或悬浮液显示出不同百分比的2-氨基芴和对氨基苯甲酸乙酰化。数据表明，幽门螺杆菌胞质溶胶中与大黄酸水平升高相关的NAT活性降低。抑制幽门螺杆菌的生长研究表明，大黄酸在幽门螺杆菌培养物中引起剂量依赖性抑菌活性：即，大黄酸的浓度越大，对幽门螺杆菌的生长抑制越大。对于胞质溶胶和完整细菌检查，与40 microM大黄酸共同处理后，Km和Vmax的表观值降低。该报告是大黄酸抑制幽门螺杆菌中的芳胺N-乙酰基转移酶活性和大黄酸抑制生长的第一个证明。

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