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首页> 外文期刊>Journal of applied toxicology >Effects on the central and peripheral nervous activity in rats elicited by acute administration of lead, mercury and manganese, and their combinations.
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Effects on the central and peripheral nervous activity in rats elicited by acute administration of lead, mercury and manganese, and their combinations.

机译：急性施用铅，汞和锰及其组合对大鼠中枢和周围神经活动的影响。

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摘要

Adult male Wistar rats were treated with inorganic lead, mercury and manganese, and their double combinations, in acute application. The aim was to study the effects on spontaneous and stimulus-evoked cortical, and evoked peripheral, nervous activity, to detect any interaction of the metals and any correlation between the changes caused in the spontaneous and stimulus-evoked electrical activity of the primary somatosensory cortical area, and the compound action potential of the tail nerve. In the frequency distribution of the spontaneous cortical activity, a shift to lower frequencies was seen. The cortical responses evoked by whisker or tail stimulation showed an increase of the peak-to-peak amplitude and peak latency on administration of the metals and metal combinations. With the metal combinations, synergism was observed. Correlations found between alterations of the spontaneous and evoked, or between cortical and peripheral, activity were evaluated in terms of mechanism. According to the results, combined exposure to the three heavy metals studied might lead to synergistic action, indicating an increased health risk in settings with exposure to several heavy metals.
机译：成年雄性Wistar大鼠在急性应用中用无机铅，汞和锰及其双重混合物处理。目的是研究对自发和刺激诱发的皮层以及诱发的周围神经活动的影响，以检测金属之间的任何相互作用以及初级体感皮层的自发和刺激诱发的电活动引起的变化之间的任何相关性区域，以及尾神经的复合动作电位。在自发性皮层活动的频率分布中，观察到向较低频率的转变。晶须或尾巴刺激引起的皮质反应显示，在施用金属和金属组合后，峰峰幅度和峰潜伏期增加。通过金属组合，观察到协同作用。根据机制评估了自发性和诱发性改变之间或皮层和外周活动之间发现的相关性。根据结果​​，所研究的三种重金属的联合暴露可能导致协同作用，表明在环境中暴露于几种重金属会增加健康风险。

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