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首页> 外文期刊>Journal of applied toxicology >A future approach to measuring relative skin sensitising potency: a proposal.
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A future approach to measuring relative skin sensitising potency: a proposal.

机译：一种测量相对皮肤致敏力的未来方法：一项建议。

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摘要

Current approaches to skin sensitisation risk assessment are dependent upon the availability of information regarding two fundamental parameters. Firstly, data relating to the relative skin sensitising potency of the chemical, and secondly, information regarding likely conditions of human exposure. During the past two decades, much has been achieved in terms of refining methods capable of informing these parameters. For example, the development of the local lymph node assay (LLNA) has made it possible to predict skin sensitising hazard, and to determine relative skin sensitising potency, in a way that was not possible previously. Taken together with accurate information about predicted exposure, such potency data can be used to facilitate the derivation of effective risk assessments. However, although the LLNA provides an integrated assessment of skin sensitising activity, it does require the use of experimental animals and there is growing enthusiasm for designing robust alternative approaches that will reduce or obviate that need. Progress is being made in defining alternative experimental strategies that avoid animal use, but it is clear that accurate characterisation of skin sensitisation hazards will require the effective integration of various sources of information. For this reason, we exemplify here one possible approach that, in theory, provides a framework for not only the identification of skin sensitising chemicals, but also the estimation of relative sensitising potency. This paradigm depends upon development of an understanding of the various biological, biochemical and chemical factors that impact on the allergenic properties of chemicals and the acquisition of skin sensitisation, and an ability to measure these in vitro.
机译：当前的皮肤致敏风险评估方法取决于有关两个基本参数的信息的可用性。首先，与该化学品的相对皮肤致敏能力有关的数据，其次，与人类可能接触的状况有关的信息。在过去的二十年中，在能够告知这些参数的精炼方法方面已经取得了很多成就。例如，局部淋巴结测定法（LLNA）的发展使人们有可能以以前无法实现的方式预测皮肤致敏性危险并确定相对的皮肤致敏性。结合有关预计接触量的准确信息，此类效能数据可用于促进有效风险评估的推导。然而，尽管LLNA提供了对皮肤致敏活性的综合评估，但确实需要使用实验动物，并且人们越来越热衷于设计能够减少或消除这种需求的可靠的替代方法。在确定避免使用动物的替代实验策略方面正在取得进展，但是很明显，对皮肤致敏危害的准确表征将需要有效整合各种信息来源。由于这个原因，我们在这里举例说明一种可能的方法，该方法在理论上不仅提供了一个框架，用于识别皮肤致敏化学物质，而且还提供了相对致敏效力的估计。这种范例取决于对影响化学物的过敏原特性和皮肤致敏性获得的各种生物，生化和化学因素的理解的发展，以及在体外测量这些因素的能力。

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