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首页> 外文期刊>Journal of applied toxicology >Fish multigeneration test with preliminary short-term reproduction assay for estrone using Japanese medaka (Oryzias latipes)
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Fish multigeneration test with preliminary short-term reproduction assay for estrone using Japanese medaka (Oryzias latipes)

机译：鱼的多代试验，采用日本（雌性）进行雌激素的短期短期繁殖试验

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The most potent chemicals potentially causing adverse effects on fish species are estrogens in human waste. Sewage is a source of these estrogens and it is difficult to reduce. In particular, although the bioactivity of estrone is estimated to be about half of that of estradiol, multiple studies report that more than 100 ng l(-1) of estrone can be detected in urban rivers, including discharges from sewage treatment works; approximately two times as high as estradiol. Few studies have been conducted to investigate the long-term effects of estrone on wildlife; therefore, we conducted fish multigeneration test using Japanese medaka (Oryzias latipes). Medaka were exposed to estrone for 27 weeks across three generations in environmentally relevant concentrations, being 5.74, 11.4, 24.0, 47.1 and 91.4 ng l(-1). No effects on reproduction were observed in the first generation; however, a decline in egg production and fertility was observed in the second generation exposed to 91.4 ng l(-1) estrone, which is lower than some known environmental concentrations in urban environments. Furthermore, histopathological abnormalities were observed in the third generation exposed to both 47.1 and 91.4 ng l(-1), suggesting that estrone possibly exerts severe effects on the third or later generations. However, appearances of testis-ova were observed in the second and third generation they were not consistent with actual effects on reproduction, notwithstanding the testis-ova is regarded as the key evidence for endocrine disruption. Accordingly, we consider that qualitative measurement of abnormalities using histopathological observations is required for appropriate evaluation of endocrine disruption. Copyright (c) 2014 John Wiley & Sons, Ltd.
机译：可能对鱼类造成不利影响的最有效的化学物质是人类废物中的雌激素。污水是这些雌激素的来源，很难减少。尤其是，尽管估计雌酮的生物活性约为雌二醇的一半，但多项研究报告表明，在城市河流中，包括污水处理厂的排放物中，可以检测到100 ng l（-1）以上的雌酮。大约是雌二醇的两倍。很少有研究调查雌酮对野生动植物的长期影响。因此，我们使用日本（Oryzias latipes）进行了鱼类多代试验。 Medaka在三代中以与环境相关的浓度分别为5.74、11.4、24.0、47.1和91.4 ng l（-1）暴露于雌酮27周。在第一代中没有观察到对繁殖的影响。但是，在暴露于91.4 ng l（-1）雌酮的第二代中，观察到鸡蛋生产和生育力下降，这低于城市环境中的某些已知环境浓度。此外，在暴露于47.1和91.4 ng l（-1）的第三代中观察到组织病理学异常，这表明雌酮可能对第三代或后代产生严重影响。然而，尽管第二代和第三代睾丸卵子被认为是内分泌破坏的关键证据，但在第二代和第三代观察到它们与生殖的实际效果并不一致。因此，我们认为需要使用组织病理学观察对异常进行定性测量，以适当评估内分泌干扰。版权所有（c）2014 John Wiley＆Sons，Ltd.

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