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首页> 外文期刊>Journal of applied toxicology >Effect of lupeol, a pentacyclic triterpene, on the lipid peroxidation and antioxidant status in rat kidney after chronic cadmium exposure.
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Effect of lupeol, a pentacyclic triterpene, on the lipid peroxidation and antioxidant status in rat kidney after chronic cadmium exposure.

机译：五环萜烯五萜酚对慢性镉暴露后大鼠肾脏脂质过氧化和抗氧化状态的影响。

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摘要

This study pertains to the role of lupeol, a pentacyclic triterpene, against the toxic manifestations of chronic cadmium exposure. Cadmium is a potent nephrotoxin on prolonged exposure. Cadmium (as cadmium chloride) at a dose of 1 mg kg(-1) body weight was administered subcutaneously for 15 days to rats. This led to an increase in the level of lipid peroxides and a decrease in the level of antioxidants in the kidney. Lupeol, when supplemented at a dosage of 40 mg kg(-1) body weight concurrent with cadmium administration, showed an improvement in the antioxidant status. The level of lipid peroxides also showed a significant decrease, which shows the nephroprotective action of the drug.
机译：这项研究与五环萜三萜萜烯萜酚对慢性镉暴露的毒性表现有关。镉是长时间暴露的有效肾毒素。向大鼠皮下注射1 mg kg（-1）体重的镉（作为氯化镉）。这导致脂质过氧化物水平的增加和肾脏中抗氧化剂水平的下降。 Lupeol在以40 mg kg（-1）体重的剂量补充镉的同时补充使用时，抗氧化剂状态得到改善。脂质过氧化物的水平也显示出显着降低，这表明该药物具有肾脏保护作用。

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