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首页> 外文期刊>Journal of applied toxicology >Epidermal cytokines in murine cutaneous irritant responses.
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Epidermal cytokines in murine cutaneous irritant responses.

机译：表皮细胞因子对小鼠皮肤有刺激性反应。

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摘要

Investigations on cytokines in skin irritancy or non-immunological irritant contact dermatitis (ICD) should improve our understanding of their complex mechanism. Numerous studies showed, however, that similar epidermal cytokines have been detected in irritant and allergic reactions, suggesting a lack of specific cytokines that clearly differentiate allergic from irritant reactions even though the pathomechanisms between allergic contact dermatitis (ACD) and ICD are distinguished. Recent data, however, indicate that some mediators may be restricted to allergic responses (contact hypersensitivity). This could provide the impetus to study their implication on irritant reactions. We overview the epidermal cytokines involved in irritant responses compared to those in contact hypersensitivity based on published results of studies using in vitro cell-cultured murine keratinocytes and in vivo murine models. Copyright 2000 John Wiley & Sons, Ltd.
机译：对皮肤刺激性或非免疫刺激性接触性皮炎（ICD）中细胞因子的研究应增进我们对其复杂机制的了解。然而，大量研究表明，在刺激性和过敏性反应中已检测到相似的表皮细胞因子，这表明尽管能区分过敏性接触性皮炎（ACD）和ICD的致病机理，但缺乏能清楚地区分过敏性反应和刺激性反应的特异性细胞因子。但是，最近的数据表明，某些介体可能仅限于过敏反应（接触性超敏反应）。这可以为研究其对刺激性反应的影响提供动力。基于使用体外细胞培养的鼠角质形成细胞和体内鼠模型的研究结果，我们概述了与接触性超敏反应相比与刺激反应有关的表皮细胞因子。版权所有2000 John Wiley＆Sons，Ltd.

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