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首页> 外文期刊>Journal of applied toxicology >Toxicity of trichloroethylene following inhalation and drinking contaminated water.
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Toxicity of trichloroethylene following inhalation and drinking contaminated water.

机译：吸入和喝受污染的水后，三氯乙烯的毒性。

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The neurobehavioural effects of trichloroethylene (TCE) were studied in rats following administration of the solvent orally (350, 700 and 1400 ppm in drinking water for 90 days) and through inhalation (376 ppm for 4 h a day, 5 days per week for 180 days). Various aspects of spontaneous locomotor activity were assessed at different periods after exposure through either of the routes. Oral exposure to TCE had no significant effect on spontaneous locomotor activity or cognitive ability, whereas inhalation to the solvent resulted in an increase in the distance travelled and horizontal activity counts at day 30 but a decrease at day 60 of exposure. The time spent in ambulatory and stereotypic movements as well as the number of stereotypic movements were enhanced significantly only at day 30. The resting time was decreased at day 30 but enhanced at day 60 of exposure. The learning ability was not affected significantly up to day 180. The results highlight the neurotoxic potential of inhalation exposure to TCE.
机译：口服给予溶剂（饮用水中350、700和1400 ppm，持续90天）并通过吸入（376 ppm，持续4天，每周5天，持续180天）对三氯乙烯（TCE）的神经行为进行研究。 ）。通过任一途径暴露后，在不同时期评估自发运动能力的各个方面。口服暴露于三氯乙烯对自发运动能力或认知能力无显着影响，而吸入溶剂导致第30天的行进距离和水平活动数量增加，但第60天减少。仅在第30天，走动和定型运动所花费的时间以及定型运动的次数才显着增加。在接触的第30天，休息时间减少，但在接触的第60天，休息时间增加。直到第180天，学习能力都没有受到显着影响。结果表明，吸入接触TCE可能具有神经毒性。

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